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Epidemiology

Home Archive by category "Epidemiology"

Pre-Pandemic Hospital Surge Capacity ‘Time Capsule’

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Epidemiology, Featured News | April 7, 2021

A University of Pittsburgh School of Medicine-led survey of dozens of surge capacity managers at hospitals nationwide captures the U.S. health care system’s pandemic preparedness status in the months before the first COVID-19 cases were identified in China. McGowan Institute for Regenerative Medicine affiliated faculty member Derek Angus, MD, MPH, Executive Vice President, and Chief Healthcare Innovation Officer, UPMC; Associate Vice Chancellor for Healthcare Innovation, University of Pittsburgh Schools of the Health Sciences; Distinguished Professor and Mitchell P. Fink Endowed Chair, Department of Critical Care Medicine, University of Pittsburgh and UPMC; Senior editor, JAMA, is a co-author of the study published in the journal JAMA Network Open. Read More

Pitt Scientists Find the Key to Viral-Bacterial Co-Infection

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | February 24, 2021

The mechanism by which acute viral respiratory infections promote secondary bacterial growth and infection in the airways depends on iron-carrying extracellular sacs secreted by the cells lining the host’s airways, report researchers from the University of Pittsburgh School of Medicine in a paper published in Cell Reports.  McGowan Institute for Regenerative Medicine faculty member Donna Stolz, PhD, associate director of the Center for Biologic Imaging, University of Pittsburgh School of Medicine, and an associate professor in the Departments of Cell Biology and Pathology at the University of Pittsburgh, is a co-author on the paper. Read More

Will the Science of Aging Reversal Come into Its Own in 2021?

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | January 21, 2021
rando

As reported by Heather McKenzie from BioSpace, when our backs were against the wall, the biotech/biopharma community came together to create not one, but two COVID-19 vaccines currently approved for emergency use in the U.S. The lessons learned from the global pandemic are expected to translate to existing and emerging therapeutic areas – particularly, oncology; more efficient regulatory-industry relationships; mRNA is a word we will continue to hear a lot about; and home health care is here to stay. These are just a few of the insights Ms. McKenzie discovered when she recently spoke with 12 executives from the biotech/biopharma space. Read More

Cystic Fibrosis Foundation Announces Research Agreements to Advance Its Path to a Cure

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | January 13, 2021
feinberg

The Cystic Fibrosis Foundation announced $1.7 million in new research funding to drive progress on its Path to a Cure. The awards, to seven academic institutions and two companies, will support focused research into key scientific challenges associated with developing therapies to address the underlying cause of disease for all people with CF, regardless of their underlying mutation. Read More

Overlooked Treatment May Improve Survival Rates for Ovarian Cancer Patients

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | January 6, 2021
Linkov-Faina

A treatment that may improve the 10-year survival rate for ovarian cancer patients should be a consideration, according to a recent study led by McGowan Institute for Regenerative Medicine affiliated faculty member Faina Linkov, PhD, MPH, chair of Duquesne University’s Health Administration and Public Health program in the Rangos School of Health Sciences. Read More

Two Teams of Pitt Students Launch Experiments to International Space Station

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology, International Space Station | December 23, 2020
drs v and v

Students from the University of Pittsburgh’s Swanson School of Engineering and the School of Pharmacy designed and prepared experiments that will be conducted aboard the International Space Station (ISS). Read More

Positive Effects of Physical Activity in Bariatric Surgery Patients

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology, Featured News | December 9, 2020
stephen-belle

In a recent issue of the Annals of Surgery, epidemiologists from the University of Pittsburgh published an analysis that could help guide clinicians and policymakers in counseling bariatric surgery patients to improve their quality of life for many years to come.  McGowan Institute for Regenerative Medicine affiliated faculty member Steven Belle, PhD, MScHyg, professor in the Department of Epidemiology and a co-director in the Epidemiology Data Center in the Graduate School of Public Health at the University of Pittsburgh, is a co-author on the study. Read More

Hydroxychloroquine Doesn’t Help COVID-19 In Patients

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Epidemiology | November 11, 2020
new angus

UPMC and University of Pittsburgh School of Medicine physician-scientists—including McGowan Institute for Regenerative Medicine affiliated faculty member Derek Angus, MD, MPH, UPMC chief healthcare innovation officer, chair of the UPP Department of Critical Care Medicine and physician director of the UPMC ICU Service Center, University of Pittsburgh’s inaugural associate vice chancellor for health care innovation, and Distinguished Professor and the Mitchell P. Fink Endowed Chair in Critical Care Medicine at the University of Pittsburgh School of Medicine—contributed to a national study published in the Journal of the American Medical Association (JAMA) reporting findings that “do not support” the use of hydroxychloroquine for the treatment of adult patients hospitalized with COVID-19. Read More

Questionnaire-Based Tool Measures Fatigue in Patients Receiving Dialysis

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | November 11, 2020
2020 Dew Mary Amanda

A recent study has validated a new patient-reported outcome measure that assesses fatigue in patients receiving long-term dialysis treatments. The results appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).  McGowan Institute of Regenerative Medicine affiliated faculty member Mary Amanda Dew, PhD, Professor of Psychiatry, Psychology, Epidemiology, Nursing, and Biostatistics at the University of Pittsburgh and also a Professor at the Clinical and Translational Science Institute, is a co-author on this study. Read More

Steroids Improve Survival in Very Ill COVID-19 Patients

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Epidemiology | September 9, 2020
new angus

In a tremendous demonstration of global collaboration, an international team led by clinician-scientists at UPMC and the University of Pittsburgh School of Medicine have pooled data from 121 hospitals in eight countries to find that inexpensive, widely available steroids improve the odds that very sick COVID-19 patients will survive the illness. Read More

Plexiglass Alone Can’t Protect Against Aerosolized Virus

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Epidemiology | September 9, 2020
aerosol box

Especially in settings where personal protective equipment, or PPE, is in short supply, intubation — inserting a breathing tube down a patient’s throat — poses a major risk of SARS-CoV-2 exposure for doctors and nurses as viral particles are released into the air. Read More

Drs. Alan Wells and Louis Falo Receive Clinical and Translational Science Institute Awards to Support Urgent COVID-19 Research

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Epidemiology | April 29, 2020
drs w and f

The Clinical and Translational Science Institute (CTSI) at the University of Pittsburgh has awarded $900,000 to 17 research projects to address different aspects of the COVID-19 pandemic.  McGowan Institute for Regenerative Medicine affiliated faculty members Alan Wells, MD, DMSc, and Louis Falo, MD, PhD, will serve as co-principal investigators on two of the funded projects.  Their projects and funding are: Read More

UPMC Children’s Receives FCC COVID-19 Telehealth Program Grant to Help Immunocompromised Children

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Epidemiology | April 29, 2020
MazariegosGeorge

The Federal Communications Commission (FCC) has awarded the Hillman Center for Pediatric Transplantation at UPMC Children’s Hospital of Pittsburgh with one of the first six grants from the COVID-19 Telehealth Program Fund — and the first to a children’s hospital. Read More

UPMC-Led Global Effort Fast Tracks Testing of COVID-19 Therapies

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Epidemiology | April 15, 2020
new angus

Launched recently at UPMC is a novel clinical trial developed by researchers at the University of Pittsburgh School of Medicine to address one of the most important debates during the COVID-19 pandemic: How should doctors decide between quickly adopting new therapies, such as the anti-malarial drug hydroxychloroquine, and waiting until they are tested in longer clinical trials? Read More

COVID-19 Vaccine Candidate Shows Promise

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Drug Delivery, Epidemiology | April 8, 2020
falo covid19 drug delivery system

University of Pittsburgh School of Medicine scientists announced a potential vaccine against SARS-CoV-2, the new coronavirus causing the COVID-19 pandemic. When tested in mice, the vaccine, delivered through a fingertip-sized patch, produces antibodies specific to SARS-CoV-2 at quantities thought to be sufficient for neutralizing the virus. Read More

UPMC Close to Immunity Test that Could Help End COVID-19 Lockdown

By The McGowan Institute For Regenerative Medicine | CoVid-19, Current News, Epidemiology | April 8, 2020
covid19

As reported by David Templeton for the Pittsburgh Post-Gazette, UPMC researchers are close to completing a blood test to determine immunity against the virus that causes COVID-19.  Such a test could certify little or no risk of SARS-CoV-2 infection and identify the so-called “super” people who could serve in the health-care battle against COIVD-19 with little risk to themselves. Read More

Intralipid Improves Efficacy of Chemotherapy Treatment

By The McGowan Institute For Regenerative Medicine | Cancer, Current News, Epidemiology | March 25, 2020
hochien

Pairing chemotherapy nanodrugs with a nutritional supplement can lessen devastating side-effects while reducing the amount of the expensive drugs needed to treat cancer according to a study from Carnegie Mellon University (CMU) and Taiwan’s National Health Research Institutes (NHRI). In addition, pretreatment with the supplement promotes the production of tumor-killing macrophages, making it a promising complement and supplement to existing chemotherapies. Read More

Alcohol in Her Urine, But Not in Her Blood: Putting the Puzzle Pieces Together

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | March 19, 2020
tamama 2019

Auto-brewery syndrome is a rare medical condition in which intoxicating quantities of ethanol are produced by specific types of yeast or bacteria through endogenous fermentation in the digestive system.  McGowan Institute for Regenerative Medicine affiliated faculty member Kenichi Tamama, MD, PhD, FCAP, Associate Professor of Pathology at the University of Pittsburgh School of Medicine and Director of the Toxicology Laboratory, and colleagues have reported in the Annals of Internal Medicine the first known case of a woman who urinates alcohol after a never-before-seen condition effectively turned her bladder into a microbrewery. Read More

Smoking Relapse Common in Weight-Loss Surgery Patients

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | February 26, 2020
Belle2018

Although 1 in 7 adults smoke cigarettes the year prior to undergoing weight-loss surgery, nearly all successfully quit at least a month before their operation. However, smoking prevalence steadily climbs to pre-surgery levels within seven years, according to new research led by the University of Pittsburgh Graduate School of Public Health.  McGowan Institute for Regenerative Medicine affiliated faculty member Steven Belle, PhD, MScHyg, Professor in the Department of Epidemiology and a Co-Director in the Epidemiology Data Center, Graduate School of Public Health at the University of Pittsburgh, is a co-author on this work. Read More

Using Regenerative Biology to Restore Mucus Production

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | February 12, 2020
davidson lance

Mucus is a protective, slimy secretion produced by goblet cells and which lines organs of the respiratory, digestive, and reproductive systems. Slime production is essential to health, and an imbalance can be life-threatening. Patients with diseases such as asthma, chronic obstructive pulmonary disease (COPD), and ulcerative colitis produce too much mucus, often after growing too many goblet cells. Loss of goblet cells can be equally devastating – for instance during cancer, after infection, or injury. The balance of slime creation, amount, and transport is critical, so doctors and medical researchers have long sought the origins of goblet cells and have been eager to control processes that regenerate them and maintain balanced populations. Read More

Rupture of Intracranial Aneurysms—How the Right Tools Help Find the Cause

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | February 5, 2020
5a Anne Robertson

Sometimes, in order to understand the big picture, you need to start by assessing the smallest of details. It’s a truth that engineers know well — selecting the right materials can mean the success or failure of a given application. Read More

Vitamin D Linked to Better Blood Pressure in Pittsburgh Kids

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | February 5, 2020
Vallejo2

Overweight and obese vitamin D-deficient children who took a relatively high dose of vitamin D every day for six months had lower blood pressure and improved insulin sensitivity than their peers who took a lower dose, according to the results of a UPMC Children’s Hospital of Pittsburgh clinical trial reported in The American Journal of Clinical Nutrition.  McGowan Institute for Regenerative Medicine affiliated faculty member Abbe de Vallejo, PhD, Associate Professor of Pediatrics and Immunology in the School of Medicine at the University of Pittsburgh, is a co-author on the study. Read More

Sepsis Kills 1 in 5 Globally, Double Previous Estimate

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | January 29, 2020
new angus

Twice as many people as previously believed are dying of sepsis worldwide, according to an analysis published in The Lancet and announced at the Critical Care Reviews annual meeting in Belfast. Among them are a disproportionately high number of children in poor areas. Read More

Salama Lab Study Reveals How Relaxin Targets Cardiovascular Disease

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | January 15, 2020
salama study

As a healthy heart ages, it becomes more susceptible to cardiovascular diseases. Though researchers have discovered that relaxin, an insulin-like hormone, suppresses atrial fibrillation (AF), inflammation, and fibrosis in aged rats, the underlying mechanisms of these benefits are still unknown. In a recent Scientific Reports paper, a University of Pittsburgh research team discusses how relaxin interacts with the body’s signaling processes to produce a fundamental mechanism that may have great therapeutic potential. Read More

And the Beep Goes On: CMU/UPMC Collaborative Effort Unravels Medical Mysteries

By The McGowan Institute For Regenerative Medicine | Current News, Epidemiology | January 8, 2020
1b drs p and c

Artur Dubrawski, PhD, is not a critical care physician, but his best friend is. Dr. Dubrawski, a research professor in Carnegie Mellon University’s Robotics Institute, loves talking about disease symptoms with McGowan Institute for Regenerative Medicine affiliated faculty member Michael Pinsky, MD, a professor of critical care medicine, cardiovascular disease, bioengineering and more at the University of Pittsburgh Medical Center. They also love talking about data and, more important, what the data means. Read More

Dr. Dennis McNamara to Chair Clinical Steering Committee for Trial to Treat Acute Myocarditis

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | December 11, 2019
1b mcnamara

Cardiol Therapeutics Inc., a leader in the production of pharmaceutical cannabidiol (CBD) products and in the development of innovative cannabidiol medicines for heart disease, announced the formation of the Clinical Steering Committee (CSC) for a Phase 2 international trial in acute myocarditis using its CardiolRx™100 cannabidiol formulation. Read More

Pitt School of Dental Medicine Goes Opioid-Free

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | December 4, 2019
costello2018

The University of Pittsburgh School of Dental Medicine is the first in the nation to establish opioid-free pain management guidelines for the vast majority of procedures performed in all of its clinics. Read More

Metastatic Breast Cancer Research Receives A Glimmer of Hope Foundation Funding

By The McGowan Institute For Regenerative Medicine | Cancer, Cellular Therapy, Epidemiology, News Archive | November 20, 2019
Oesterreich

Magee-Womens Research Institute (MWRI) has received $112,500 in funding from A Glimmer of Hope Foundation (GOH) to further research of metastatic breast cancer (MBC) and to enhance patient support services at UPMC Magee-Womens Hospital. Read More

β-blockers Build Heart Muscle

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | November 4, 2019
kuhn2018sm

Surgery can mend congenital heart defects shortly after birth, but those babies will carry a higher risk of heart failure throughout the rest of their lives. Yet, according to a Science Translational Medicine study published by UPMC Children’s Hospital of Pittsburgh researchers, β-blockers could supplement surgery to regenerate infant heart muscle and mitigate the lasting effects of congenital heart disease. Read More

SPRY Clinical Trial Is First of Its Kind

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | October 23, 2019
new angus

Jenny Blair, writer for PittMed, reports in her article that in April 2019, Pitt began enrolling patients in one of the world’s first trials that combines the electronic health record with a new, efficient, safety-focused randomization process. The system is powered by software created by the Texas-based Berry Consultants. The approach, called REMAP (randomized, embedded, multi-factorial, adaptive platform), may transform the way doctors learn from patients—and how they care for them. Read More

NIH Grant: $21.5 million to Establish the LB3P MRC

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | October 21, 2019
lumbar region

Primary investigators Gwendolyn Sowa, MD, PhD, of Pitt’s Department of Physical Medicine and Rehabilitation and the UPMC Rehabilitation Institute, and McGowan Institute for Regenerative Medicine affiliated faculty member Nam Vo, PhD, of the Department of Orthopaedic Surgery, were awarded $21.5 million to establish the Low Back Pain: Biological, Biomechanical, Behavioral Phenotypes Mechanistic Research Center (LB3P MRC), a multidisciplinary research center dedicated to categorizing patients into chronic low back pain subgroups with the goal of targeting treatments specific to individual patients’ pain and reducing the use of opioids. Read More

Potential Treatment of Metastatic Solid Tumors Receives Funding Boost

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | September 25, 2019
new josephglorioso

Oncorus, Inc., an oncolytic virus company focused on driving innovation to transform outcomes for cancer patients, announced recently the completion of an oversubscribed $79.5 million Series B financing.  Oncorus is a University of Pittsburgh spin-out company based on the pioneering research of McGowan Institute for Regenerative Medicine affiliated faculty member Joseph Glorioso III, PhD, Professor in the Department of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine with a secondary appointment in the Department of Human Genetics, University of Pittsburgh Graduate School of Public Health.  Dr. Glorioso is a co-founder of Oncorus and heads its Scientific Advisory Board. Read More

Strawberries May Be Key to Developing an Insulin Pill

By The McGowan Institute For Regenerative Medicine | Drug Delivery, Epidemiology, News Archive | September 18, 2019
whitehead 2019

More than 30 million Americans suffer from diabetes and must inject themselves with insulin two to four times daily. Researchers have been looking for ways to administer the drug orally, and researchers at Carnegie Mellon University (CMU) have now shown such a feat is possible. Read More

Runaway Mitochondria Cause Telomere Damage in Cells

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | September 11, 2019
pitt van houten

Researchers at the University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center—including McGowan Institute for Regenerative Medicine affiliated faculty member Simon Watkins, PhD, founder and director of the Center for Biologic Imaging at the University of Pittsburgh, a member of the Pittsburgh Cancer Institute, and a distinguished professor and vice chairman within the Department of Cell Biology—provide the first concrete evidence for the long-held belief that sick mitochondria pollute the cells they’re supposed to be supplying with power. Read More

Vorp Lab Using Amazon Web Services to Diagnose/Treat Abdominal Aortic Aneurysms

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | September 4, 2019
vorpd

McGowan Institute for Regenerative Medicine affiliated faculty member David Vorp, PhD, associate dean for research at Pitt’s Swanson School of Engineering and the John A. Swanson Professor of Bioengineering, and his team are using Amazon Web Services (AWS) resources to improve the diagnosis and treatment of abdominal aortic aneurysms, the 13th-leading cause of death in western countries. New machine learning technologies and advances in computing power, like those offered by Amazon SageMaker and Amazon EC2, are making it possible to rapidly translate insights discovered in the lab into treatments and services that could dramatically improve human health. Read More

Study: Inflammation Persists in Sepsis Survivors

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | August 28, 2019
drs a and k

One out of four sepsis patients who survive their hospital stay have elevated levels of inflammation a year after discharge, and they are at higher risk for major health problems and death, according to a study led by physician-scientists at the University of Pittsburgh School of Medicine and the Veterans Affairs Pittsburgh Healthcare System.  McGowan Institute for Regenerative Medicine affiliated faculty members who are authors on this study include: Read More

First Ever State Sepsis Regulation Tied to Lower Death Rates

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | August 14, 2019
new angus

Death rates from sepsis fell faster in New York than expected—and faster than in peer states—following the introduction of the nation’s first state-mandated sepsis regulation, according to an analysis led by University of Pittsburgh researchers and published in JAMA. The policy requires all New York hospitals to quickly implement certain protocols when the deadly condition is suspected. Read More

Dr. Mangesh Kulkarni Receives $18K Award from Pitt’s Central Research Development Fund

By The McGowan Institute For Regenerative Medicine | Epidemiology, News Archive | August 14, 2019
kulkarni

McGowan Institute for Regenerative Medicine affiliated faculty member Mangesh Kulkarni, PhD, assistant professor of bioengineering at the University of Pittsburgh Swanson School of Engineering, was awarded $17,793 in funding from the Central Research Development Fund (CRDF) to support research for the treatment of inflammatory bowel disease (IBD). Read More

New Alliance with the International Space Station U.S. National Laboratory

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Epidemiology, International Space Station, News Archive, Tissue Engineering | August 12, 2019
ISS

The McGowan Institute has formed an alliance with the International Space Station (ISS) U.S. National Laboratory to develop and demonstrate how microgravity can improve regenerative medicine-based therapies. The ISS provides a unique platform to conduct studies in a microgravity environment. Read More

Pitt First to Grow Genetically Engineered Mini Livers in the Lab to Study Disease and Therapies

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Epidemiology, News Archive | August 7, 2019
drs s-g and f

Researchers at the University of Pittsburgh School of Medicine—including McGowan Institute for Regenerative Medicine affiliated faculty members Alejandro Soto-Gutierrez, MD, PhD, associate professor of pathology at Pitt’s School of Medicine and faculty member of the Pittsburgh Liver Research Center, and Ira Fox, MD, professor of surgery and pediatric transplantation at UPMC Children’s Hospital of Pittsburgh—are the first to grow genetically modified miniature human livers in the laboratory, to emulate human liver disease progression and test therapeutics. Read More

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