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Cellular Therapy

Media Cellular Therapy

The Force to Shape an Organ

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News, Featured News | January 21, 2021
feinberg work

Carnegie Mellon University’s Biomedical Engineering and Materials Science and Engineering Professor Adam Feinberg, PhD, along with postdoctoral fellow Dan Shiwarski, PhD, and graduate student Joshua Tashman have created a novel biosensor that reveals the mechanobiological forces that shape organ development.  Dr. Feinberg is also an affiliated faculty member of the McGowan Institute for Regenerative Medicine.

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Genprex Strengthens Scientific Advisory Board with Appointment of Dr. George Gittes

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | November 25, 2020
Gittes

Genprex, Inc., a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, announced the addition of George Gittes, MD to its Scientific Advisory Board (SAB). Dr. Gittes is the inventor of the Company’s licensed diabetes gene therapy technology that is currently in development and serves as the Chief of Pediatric Surgery and Surgeon-in-Chief Emeritus at the UPMC Children’s Hospital of Pittsburgh.

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Roy Lab Research Featured in JBC Special Virtual Issue

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | November 4, 2020
roy lab pix

Animals, plants, fungi, and protozoans all have eukaryotic cells, and the cytoskeleton in these systems plays an important role in cell shape, movement, and division. Disruption in this complex network of protein filaments can lead to cell and organ dysfunction.

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Editing the Immune Response to Boost Gene Therapy

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | September 16, 2020
drs k and e

Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing sequence or enact a temporary change in its expression, but the body’s immune response to AAV can thwart the whole endeavor.

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Calcium Helps Build Strong Cells

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | September 16, 2020
KrisDahl_188

Every time you flex your bicep or stretch your calf muscle, you put your cells under stress. Every move we make throughout the day causes our cells to stretch and deform. But this cellular deformation can be dangerous and could potentially lead to permanent damage to the DNA in our cells, and even cancer. So how is it that we’re able to keep our bodies moving without constantly destroying our cells? Thanks to a new study by McGowan Institute for Regenerative Medicine affiliated faculty member and Carnegie Mellon University (CMU) Chemical Engineering Professor Kris Dahl, PhD, and Associate Professor Sara Wickström, MD, PhD, of the University of Helsinki, we now know that the answer lies in a humble mineral we consume every day.

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Organ Regeneration Technology Is Focus of Four Peer-Reviewed Publications

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | September 2, 2020
drs l f and f

LyGenesis, Inc., a biotechnology company focused on regenerative medicine founded by McGowan Institute for Regenerative Medicine faculty member Eric Lagasse, PharmD, PhD, recently announced the publication of four peer-reviewed papers on its organ regeneration technology.  Dr. Lagasse is LyGenesis’s Chief Scientific Officer, Associate Professor in the Department of Pathology at the University of Pittsburgh, and Director of the Cancer Stem Cell Center at the McGowan Institute.  Dr. Lagasse is a co-author on each of the publications.

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Pigs Grow New Liver in Lymph Nodes, Study Shows

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | August 26, 2020
lagasse pig liver lymph nodes

Hepatocytes — the chief functional cells of the liver — are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply. In a new study published in the journal Liver Transplantation, researchers at the University of Pittsburgh School of Medicine showed that large animals with ailing livers can grow a new organ in their lymph nodes from their own hepatocytes. A human clinical trial is next.

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Welcome: Dr. Samira Kiani

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | July 29, 2020
kiani 2020

The McGowan Institute for Regenerative Medicine welcomes new affiliated faculty member Samira Kiani, MD.

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Dr. Sachin Velankar Receives NSF Grant

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | July 29, 2020
velankar

McGowan Institute for Regenerative Medicine affiliated faculty member Sachin Velankar, PhD, Professor, Department of Chemical & Petroleum Engineering, Swanson School of Engineering, University of Pittsburgh, recently was awarded a National Science Foundation grant for his proposal entitled “Collaborative Research: Micromechanics of Meniscus-bound Particle Clusters.”  Dr. Valenkar shares this grant with Charles Schroeder, PhD, Associate Head and Ray and Beverly Mentzer Professor, Department of Chemical & Biomolecular Engineering, University of Illinois at Urbana-Champaign.  The award is for three years for a total of $510,000 ($292K as the Pitt portion).

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UPMC Children’s and Pitt Researcher Receives $2.59 Million NIH Grant for Diabetes Gene Therapy

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | July 22, 2020
Gittes

The National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases has awarded a grant of $2.59 million to George Gittes, MD, director of the Richard King Mellon Foundation Institute for Pediatric Research, co-scientific director at UPMC Children’s Hospital of Pittsburgh, and affiliated faculty member of the McGowan Institute for Regenerative Medicine, to support continuing development of gene therapy technology that may have the potential to cure Type 1 and Type 2 diabetes, which affects approximately 10% of the U.S. population, or more than 34 million people.

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Reversing Drug Resistance in Breast Cancer

By The McGowan Institute For Regenerative Medicine | Cancer, Cellular Therapy, Current News | July 22, 2020
fibroblasts

Roughly one in eight women in the United States will develop invasive breast cancer over the course of  her lifetime, and HER2-positive (HER2+) breast cancers represent about 25 percent of all breast cancer cases. Though multiple therapies exist, most patients will develop metastatic disease and resistance to current treatments.

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Podcast: Liver Disease Research and Potential Treatments with Dr. Alejandro Soto-Gutiérrez

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | July 15, 2020
Soto-Gutierrez

Today in the United States there are millions of people suffering from liver disease which makes it the second cause of liver transplant.  Only 30-35% of those in need of a liver will receive one.  Approximately 30,000 people per year will die from liver disease.

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Welcome: Dr. Tirthadipa Pradhan

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | July 8, 2020
dipa phd

The McGowan Institute for Regenerative Medicine welcomes new affiliated faculty member Tirthadipa Pradhan, PhD.

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Welcome: Dr. Mo Ebrahimkhani

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | July 1, 2020
mo

The McGowan Institute for Regenerative Medicine welcomes new affiliated faculty member Mo Ebrahimkhani, MD.

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‘Cell-Soldiers’ Turn Out to Be More Resistant Than ‘Cell-Combat Medics’

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Computations and Modeling, Current News | June 24, 2020
drs k and b

Researchers from Sechenov University and University of Pittsburgh discovered that the resistance of innate immune cells, macrophages, to ferroptosis – a type of programmed cell death – depends on the type of their activation. It turned out that cells helping tissues to recover from inflammation were more vulnerable. The researchers identified the mechanisms underlying the cells’ resistance and explained how this research would help regulate inflammation in a paper published in Nature Chemical Biology.  McGowan Institute for Regenerative Medicine affiliated faculty members Valerian Kagan, PhD, DSc, Professor and Vice-Chairman in the Department of Environmental and Occupational Health as well as a Professor in the Department of Pharmacology and Chemical Biology, the Department of Radiation Oncology, and the Department of Chemistry at the University of Pittsburgh, and Ivet Bahar, PhD, Distinguished Professor, the John K. Vries Chair, and the Founding Chair in the Department of Computational & Systems Biology at the University of Pittsburgh’s School of Medicine, are co-authors on the study.

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Lab-Grown Miniature Human Livers Successfully Transplanted in Rats

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News, Transplantation | June 3, 2020
drs s d and f

Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats.

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The Future of Human Healing May Lay in the Brain of a Starfish

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | April 22, 2020
KrisDahl_188

The potential benefits of stem cell therapy have been widely discussed for decades. Potential benefits include reduction of the pain of arthritis and help patients heal faster after surgery. But stem cell therapies can be prohibitively expensive. At the projected costs, these potential life-changing treatments would be far out of range of the vast majority of those who need them. But thanks to Carnegie Mellon University’s Kris Dahl, PhD, professor of chemical engineering, and Veronica Hinman, PhD, head of CMU’s Department of Biological Sciences, stem cell therapy could get a lot less expensive. And the key to this approach lies in the incredible regenerative powers of starfish.

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NeuBase Therapeutics Announces Positive, Preclinical Data Validating its Novel Genetic Therapy PATrOL™ Platform

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | April 22, 2020
stephan

NeuBase Therapeutics, Inc., a biotechnology company developing next-generation antisense oligonucleotide (“ASO”) therapies to address genetic diseases, recently announced positive preclinical data from its pharmacokinetics studies in non-human primates (“NHPs”) and in vitro pharmacodynamics data in patient-derived cell lines. NeuBase believes these data validate the key advantages of the proprietary NeuBase peptide-nucleic acid (“PNA”) antisense oligonucleotide (PATrOL™) platform and support the Company’s decision to advance the development of its Huntington’s disease (“HD”) and myotonic dystrophy type 1 (“DM1”) programs, as well as the potential expansion of its therapeutic pipeline into other indications.

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Old Human Cells Rejuvenated with Stem Cell Technology

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | April 15, 2020
rando

Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.  Study co-author Thomas Rando, MD, PhD, professor of neurology and neurological sciences and the director of Stanford’s Glenn Center for the Biology of Aging, is an affiliated faculty member of the McGowan Institute for Regenerative Medicine.

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Mimicking Cancer to Avoid Transplant Rejection

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News, Transplantation | April 1, 2020
white rat black leg

Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own.  McGowan Institute for Regenerative Medicine affiliated faculty members involved in the research team include:

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Dr. George Gittes’ Diabetes Gene Therapy Licensed to Genprex, Inc. Phase I Clinical Trial Next Step

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News | February 19, 2020
Gittes

Genprex, Inc., a clinical-stage gene therapy company developing potentially life-changing technologies for patients with cancer and other serious diseases, today announced that it signed an exclusive license agreement with the University of Pittsburgh for a diabetes gene therapy that may have the potential to cure Type 1 and Type 2 diabetes, which together currently affect approximately 30.3 million people in the U.S, or 9 percent of the U.S. population.

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Abbott Gets FDA Approval for Less-Invasive Heart Pump Implant Procedure

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Current News, Medical Devices | January 22, 2020
NEW Kormos Headshot

Abbott Laboratories, the Abbott Park, Illinois-based health care giant, has won approval from the U.S. Food and Drug Administration (FDA) for a less invasive surgical procedure that allows surgeons to implant the company’s heart pump without a patient undergoing open heart surgery.

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Researchers Find New Role for Dopamine in Gene Transcription and Cell Proliferation

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | December 4, 2019
freyberg 2019-1

The dopamine D2 receptor has a previously unobserved role in modulating Wnt expression and control of cell proliferation, according to a new study from the George Washington University (GW) and the University of Pittsburgh. The research, published in Scientific Reports, could have implications for the development of new therapeutics across multiple disciplines including nephrology, endocrinology, and psychiatry.  Zachary Freyberg, MD, PhD, an assistant professor of psychiatry and cell biology at the University of Pittsburgh School of Medicine and an affiliated faculty member of the McGowan Institute for Regenerative Medicine, is a senior author on the study.

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Metastatic Breast Cancer Research Receives A Glimmer of Hope Foundation Funding

By The McGowan Institute For Regenerative Medicine | Cancer, Cellular Therapy, Epidemiology, News Archive | November 20, 2019
Oesterreich

Magee-Womens Research Institute (MWRI) has received $112,500 in funding from A Glimmer of Hope Foundation (GOH) to further research of metastatic breast cancer (MBC) and to enhance patient support services at UPMC Magee-Womens Hospital.

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Dr. Dobrawa Napierala Awarded Grant to Commemorate Soft Bones 10th Anniversary and Hypophosphatasia Awareness Day

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | November 13, 2019
napierala

To commemorate Hypophosphatasia Awareness Day (October 30), Soft Bones, Inc., an organization dedicated to providing information, education and support to those affected by hypophosphatasia (HPP), awarded its tenth annual Maher Family Grant.  In commemoration of its tenth anniversary, Soft Bones awarded two grants for the first time ever.  McGowan Institute for Regenerative Medicine affiliated faculty member Dobrawa Napierala, PhD, Associate Professor of Oral Biology at the Center for Craniofacial Regeneration, University of Pittsburgh School of Dental Medicine, is one of this year’s awardees and will study adolescents and adults with HPP.

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DOD Grants $600K to Study Novel Regulator of Kidney Cancer Progression

By The McGowan Institute For Regenerative Medicine | Cancer, Cellular Therapy, News Archive | November 6, 2019
roy lab kidney

According to the American Cancer Society, kidney cancer is among the top ten most common cancers in men and women, and clear cell renal cell carcinoma (ccRCC) – the most common subtype of tumor associated with kidney cancer – accounts for more than 75 percent of cases.

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Project Receives Pitt’s Center for Medical Innovation Award in Round-1 2019 Pilot Funding

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | October 10, 2019
drs s and c

The University of Pittsburgh’s Center for Medical Innovation (CMI) awarded grants totaling $70,000 to three research groups through its 2019 Round-1 Pilot Funding Program for Early Stage Medical Technology Research and Development. McGowan Institute for Regenerative Medicine affiliated faculty member Carl Snyderman, MD, MBA, is a co-investigator on one of the selected projects, along with Garrett Coyan, MD, a surgery resident in the lab of William Wagner, PhD:

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Scientists Listed Ways of Applying Genetic Engineering to Treat Parkinson’s Disease

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Neuroscience, News Archive | October 2, 2019
1b drs c and k

Researchers of Sechenov University and University of Pittsburgh—including McGowan Institute for Regenerative Medicine affiliated faculty members

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The State of Cell-Based Therapies for Arthritis and Osteoporosis

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | October 2, 2019
tuan

A new report highlights the latest advances in cell-based therapies for the treatment of disorders of the musculoskeletal system, such as arthritis and osteoporosis, and it identifies key unanswered questions that should be addressed through ongoing research. The report is published in the Journal of Bone and Mineral Research and concurrently in the Journal of Orthopaedic Research, and was issued by a joint Task Force of the American Society for Bone and Mineral Research and the Orthopaedic Research Society.  McGowan Institute for Regenerative Medicine affiliated faculty member Rocky Tuan, PhD, Vice-Chancellor and President of The Chinese University of Hong Kong and the former Associate Director of the McGowan Institute, is the co-chair of the Task Force.

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Self-Rolling Sensors Take Heart Cell Readings in 3D

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | September 11, 2019
drs c-k and f

Researchers from Carnegie Mellon University (CMU) and Nanyang Technological University, Singapore (NTU Singapore) have developed an organ-on-an-electronic-chip platform, which uses bioelectrical sensors to measure the electrophysiology of the heart cells in three dimensions. These 3D, self-rolling biosensor arrays coil up over heart cell spheroid tissues to form an “organ-on-e-chip,” thus enabling the researchers to study how cells communicate with each other in multicellular systems such as the heart.

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Dr. Eric Lagasse Work Highlighted in Forbes

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | September 11, 2019
lagasse

As reported by Forbes contributor Robin Seaton Jefferson, LyGenesis, Inc., hopes to enter human trials in 2020 on a therapy that could potentially give patients with end stage liver disease hope for new livers without having to wait on donated organs. The technology, developed through research from McGowan Institute for Regenerative Medicine faculty member Eric Lagasse, PharmD, PhD, associate professor in the Department of Pathology at the University of Pittsburgh and LyGenesis’ Chief Scientific Officer, uses lymph nodes as bioreactors to regrow functioning organs within a patient’s own body. The research found that a variety of different cells types and tissues, including the liver, could engraft and actually grow within lymph nodes. The company is working on injecting cadaver cells into lymph nodes to grow secondary livers.

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Molecular Sensor Scouts DNA Damage and Supervises Repair

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | August 21, 2019
watkins

Study: In the time it takes you to read this sentence, every cell in your body suffers some form of DNA damage. Without vigilant repair, cancer would run rampant, and now scientists at the University of Pittsburgh have gotten a glimpse of how one protein in particular keeps DNA damage in check.

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New Alliance with the International Space Station U.S. National Laboratory

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Epidemiology, International Space Station, News Archive, Tissue Engineering | August 12, 2019
ISS

The McGowan Institute has formed an alliance with the International Space Station (ISS) U.S. National Laboratory to develop and demonstrate how microgravity can improve regenerative medicine-based therapies. The ISS provides a unique platform to conduct studies in a microgravity environment.

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Pitt First to Grow Genetically Engineered Mini Livers in the Lab to Study Disease and Therapies

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Epidemiology, News Archive | August 7, 2019
drs s-g and f

Researchers at the University of Pittsburgh School of Medicine—including McGowan Institute for Regenerative Medicine affiliated faculty members Alejandro Soto-Gutierrez, MD, PhD, associate professor of pathology at Pitt’s School of Medicine and faculty member of the Pittsburgh Liver Research Center, and Ira Fox, MD, professor of surgery and pediatric transplantation at UPMC Children’s Hospital of Pittsburgh—are the first to grow genetically modified miniature human livers in the laboratory, to emulate human liver disease progression and test therapeutics.

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Creating Lungs “From Scratch”

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Medical Devices, News Archive | August 1, 2019
6b grey

Erica Comber, a PhD student in Carnegie Mellon University’s (CMU’s) Department of Biomedical Engineering (BME), and her colleagues in Carnegie Mellon University’s Bioengineered Organs Initiative, are working to help people with lung disease by making them new ones.

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Dr. Freddie Fu Weighs In On Unproven Stem Cell Treatments

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Education, News Archive | July 24, 2019
FuFreddie

Liz Szabo of Kaiser Health News recently reported in Time the controversary surrounding the hope vs. hype of stem cell treatments for the relief of arthritic conditions.  She notes the benefits of stem cells are hotly debated in the medical community, and federal regulators have warned the public to beware of clinics that peddle unapproved injections as a cure-all. Many doctors and ethicists say they fear the public is being misled about how well stem cells work—and whether the procedures save their money or waste it.

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Startup Focuses on Developing Catalysts for Industry

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | June 26, 2019
biohybrid solutions

Two Carnegie Mellon University (CMU) faculty members are changing the way that proteins are made for industry through their startup BioHybrid Solutions. McGowan Institute for Regenerative Medicine affiliated faculty member Krzysztof Matyjaszewski, PhD, is the J.C. Warner University Professor of Natural Sciences in the Department of Chemistry, and Alan Russell, PhD, is the Highmark Distinguished Career Professor of Chemical Engineering and former Director of the McGowan Institute.

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Drs. Peter Rubin and Albert Donnenberg Bring Adipose Cell Therapy to Italy

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | June 20, 2019
drs r and d

Patients at UPMC Salvator Mundi International Hospital in Italy will soon have increased access to innovative methods of tissue regeneration that could improve healing and outcomes with reconstructive or aesthetic plastic surgery.

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Scientists Remind Immune Cells Whose Side They Should Be On

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | June 12, 2019
kagan

An international group of scientists in the joint study of the laboratory of the Wistar Institute, University of Pittsburgh, and I.M. Sechenov First Moscow State Medical University discovered the change in activity of one of the immune cells types called neutrophils during cancer development: They begin to prevent other immune cells from fighting tumors, and thus decelerate treatment. The scientists found protein causing such changes and demonstrated that suppressing its activity in the cells delays cancer development. The research details are published in Nature.  McGowan Institute for Regenerative Medicine affiliated faculty member Valerian Kagan, PhD, Professor and Vice-Chairman in the Department of Environmental and Occupational Health as well as a Professor in the Department of Pharmacology and Chemical Biology, the Department of Radiation Oncology, and the Department of Chemistry at the University of Pittsburgh, and also the Director of the Center for Free Radical and Antioxidant Health, is a co-author of the study.

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Direct Oxidative Stress Damage Shortens Telomeres

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, News Archive | June 5, 2019
blue telomeres

The same sources thought to inflict oxidative stress on cells—pollution, diesel exhaust, smoking and obesity—also are associated with shorter telomeres, the protective tips on the ends of the chromosomal shoelace.

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