PUBLICATIONS
- Phillippi JA. On vasa vasorum: A history of advances in understanding the vessels of vessels. Sci Adv. 2022. 8 (16). PMID:35442731.
- Lee YC, Richards TD, Fantini DA, Kaczorowski DJ, Brown BN, Phillippi JA. Ascending and Descending Aortic ECM Hydrogels for Modeling Aortic Wall Biology. 5 Dec 2022. bioRxiv. 2022. DOI: 10.1101/2022.12.03.518904
- Fortunato R, Huckaby LV, Emerel LV, Scholosser V, Phillippi JA, Vorp DA, Maiti S, Gleason TG. The predictive capability of aortic stiffness index for aortic dissection among dilated ascending aortas. JTCVS. Accepted 1 Sept 2022 (in press).
- Sharma S, Hill JC, Phillippi JA* and Nain AS*. Fiber Diameter and Architecture Dictate Three-Dimensional Assembly of Pericytes into Spheroids. bioRxiv. Epub: 4 Aug 2022. DOI: 10.1101/2022.08.02.502506 *Co-corresponding authors
- Wintruba KL, Hill JC, Richards TD, Lee YC, Kaczorowski DJ, Sultan I, Badylak SF, Billaud M, Gleason TG, Phillippi JA. Adventitia-Derived Extracellular Matrix Hydrogel Enhances Contractility of Human Vasa Vasorum-Derived Pericytes via α2β1 integrin and TGFβ Receptor. J Biomed Mater Res A. 2022 Dec; 110 (12) 1912-1920. PMCID: 35770946
- Hill JC, Billaud M, Richards TD, Kotlarczyk MP, Shiva S, Phillippi JA* Gleason TG*. Layer Specific Nos3 Expression and Genotypic Distribution in Bicuspid Aortic Valve Aortopathy. European Journal of Cardiothoracic Surgery. European Journal of Cardiothoracic Surgery. 2022 Online ahead of print: 23 Apr 2022. PMID: 34560403. *Co-corresponding authors
- Jiang D, Sun W, Wu T, Zou, M, Vasamsetti SB, Zhang X, Zhao Y, Phillippi JA, Sawalha AH, Tavakoli S, Dutta P, Florentin J, Chan SY, Tollison TS, Wu D, Cui J, Huntress I, Peng X, Finkel T, Li G. Post-GWAS functional analysis of the CDKN2A/B locus identifies CUX1 as a regulator of p16INK4a expression and cellular senescence. Nature Aging. Accepted 21 Dec 2021(in press).
- Noda K, Philips BJ, Snyder ME, Phillippi JA, Sullivan M, Stolz DB, Ren X, Luketich JD, Sanchez PG. Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes. Sci Rep. 2021 Jun 10;11(1):12265. PMID: 34112915; PMCID: PMC8192744
- Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin J-H, Bais AS, Klonowski J, de Bellaing AM, Wang MS, Emerel L, Salamacha N, Wyman SK, Lee C, Li HS, Miron A, Zhang J, Wing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, and Lo CW. Common Deletion Variant Causing Protocadherin-α Deficiency Contribute to the Complex Genetics of Bicuspid Aortic Valve and Left-sided Congenital Heart Disease. HGG Advances. 2021 Jul 8;2(3). PMID: 34888534
- Emerel L, Thunes J, Kickliter T, Billaud M, Phillippi JA, Vorp DA, Maiti, S and Gleason TG. Pre-Dissection-Derived Geometric and Distensibility Indices Reveal Increased Peak Longitudinal Stress and Stiffness in Patients Sustaining Acute Type A Aortic Dissection: Implications for Predicting Dissection. J Thorac Cardiovasc Surg. 2019. 158 (2): 355-363. PubMed PMID: 30551966
- Phillippi JA, Hutcheson, JD and Aikawa E. Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine. Frontiers in Cardiovascular Medicine. 2019 Published online 2019. 6:13. PubMed PMID: 30873414
- Billaud M, Hill JC, Richards TR, Gleason TG, and Phillippi JA. Medial Hypoxia and Adventitial Vasa Vasorum Remodeling in Human Ascending Aortic Aneurysm. Frontiers in Cardiovascular Medicine. Published online 17 Sept 2018. 5:124. PubMed PMID: 30276199
- Thunes JT, Phillippi, JA, Gleason, TG, Vorp DA, and Maiti, S. Structural Modeling Reveals Microstructure-Strength Relationship for Human Ascending Thoracic Aorta. J Biomech. 2018. 71: 84-93. PubMed PMID: 29544877
- Xue Y, St. Hilaire C, Hortells L, Phillippi JA, Sant V, and Sant S. Shape Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Interstitial Valve Cells. Cell and Mol Bioeng. 2017. 10: 483.
- Hall A, Chan PG, Sheets K, Apperson M, Delaughter C, Gleason TG, Phillippi JA*, and Nain AS*. Nanonet Force Microscopy for Measuring Forces in Single Smooth Muscle Cells of Human Aorta. Mol Biol Cell. 2017. 28 (14): 1894-1900. *Co-corresponding authors. PubMed PMID: 28450452
- Billaud M*, Phillippi JA*, Kotlarczyk MP, Hill HC, Ellis BW, St. Croix CM, Cantu-Medellin N, Kelley EE, and Gleason TG. Elevated Oxidative Stress in the Aortic Media of Bicuspid Aortic Valve Patients. JTCVS (accepted 18 May 2017). *Equal contribution. (in press).
- Editorial: Mennander AA. Biochemistry- On Bicuspid Aortic ValveÂ’s Aortic Service. JTVCS. 2017 (ePub 5 June 2017).
- Editorial: Jones, JA. Oxidative Stress in Bicuspid Aortic Valve-Related Aortopathy: Hand-Me-Downs and Yoga Pants. JTVCS. 2017 (ePub 17 June 2017).
- Billaud M, Donnenberg VS, Ellis BW, Meyer EM, Donnenberg AD, Hill JC, Richards TD, Gleason TG and Phillippi JA. Classification and Functional Characterization of Vasa Vasorum-Associated Perivascular Progenitor Cells in Human Aorta. Stem Cell Reports (ePub 17 May 2017). PMID: 28552602
- Venkatesh P, Phillippi J, Chukkapalli C, Rivera-Kweh M, Velsko I, Gleason T, VanRyzin P, Ghanta R, Beaver T, Chan E, Kesavalu L. Aneurysm-specific miR-221 and miR-146a participates in Human Thoracic and Abdominal Aortic Aneurysms. International Journal of Molecular Sciences. 2017 Apr 20; 18 (4). pii e875. PMID: 28425970
- Fercana GR*, Yerneni S*, Billaud M, Hill JC, VanRyzin P, Richards TD, Sicari B, Badylak SF, Johnson S, Campbell PG, Gleason TG and Phillippi JA. Perivascular Extracellular Matrix Hydrogels Mimic Native Matrix Microarchitecture and Promote Angiogenesis via Basic Fibroblast Growth. Biomaterials. 2017 Apr;123:142-154.*Equal contribution. PMID: 28167392
- Xue Y, Yatsenko T, Patel A, Stolz DB, Phillippi J, Sant V, and Sant S. PEGylated poly(ester amide) elastomer scaffolds for soft tissue engineering. Polymers for Advanced Technologies (in press).
- Phillippi JA*, Hill JC*, Billaud M, Green BR, Kotlarczyk MP, and Gleason TG. Bicuspid Aortic Valve Morphotype Correlates with Regional Antioxidant Gene Expression Profiles in the Proximal Ascending Aorta. Ann Thor Surg. 2017 Feb 6. pii: S0003-4975(16) 31529-6. *Equal contribution. PMID: 28185644
- Kotlarczyk, MP, Billaud, M, Green, BR, Hill, JC, Kelley, EE, Shiva, S, Phillippi, JA and Gleason, TG. Regional disruptions in endothelial nitric oxide pathway associated with bicuspid aortic valve. Annals of Thoracic Surgery. 2016 102 (4) 1274-81. PMID: 27283108.
- Thunes JA, Pal S, Fortunado R, Phillippi JA, Gleason TG, Vorp DA and Maiti S. A Structural Finite Element Model for Lamellar Unit of Aortic Media Suggests Heterogeneous Stress Field After Collagen Recruitment. Journal of Biomechanics. 2016. 49 (9):1562-9. PMID: 27113538.
- Tsamis A, Phillippi JA, Koch RG, Krawiec JT, DÂ’Amore A, Watkins SC, Wagner WR, Vorp DA and Gleason TG. Extracellular Matrix Fiber Microarchitecture is Region- Specific in Bicuspid Aortic Valve-Associated Ascending Aortopathy. JTCVS. 2016. 151 (6): 1718.-28. PMID: 26979916.
- Tsamis, A, Pal, S, Phillippi, JA, Gleason, TG, Maiti, S* and Vorp, DA. Effect of Aneurysm on Biomechanical Properties of “Radially-oriented” Collagen Fibers in Human Ascending Thoracic Aortic Media. J Biomechanics. 2014 47 (16): 3820-4.
- Adams DH, Popma JJ, Reardon MJ, Yakubov SJ, Coselli JS, Deeb GM, Gleason TG, Buchbinder M, Hermiller J Jr, Kleiman NS, Chetcuti S, Heiser J, Merhi W, Zorn G, Tadros P, Robinson N, Petrossian G, Hughes GC, Harrison JK, Conte J, Maini B, Mumtaz M, Chenoweth S, Oh JK; the U.S. CoreValve Clinical Investigators. Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis. New England Journal of Medicine. 2014 Mar 29. PMID: 24678937 [Epub ahead of print]
- Pal S, Tsamis A, Pasta S, D’Amore A, Gleason TG, Vorp DA, Maiti S. A mechanistic model on the role of “radially running” collagen fibers on dissection properties of human ascending thoracic aorta. Journal of Biomechanics. 2014 Mar 21;47(5):981-8. doi: 10.1016/j.jbiomech.2014.01.005. Epub 2014 Jan 14. PMID: 24484644
- Koch RG, Tsamis A, D’Amore A, Wagner WR, Watkins SC, Gleason TG, Vorp DA. A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopy. Journal of Biomechanics. 2014 Mar 21;47(5):935-43. doi: 10.1016/j.jbiomech.2014.01.027. Epub 2014 Jan 20. PMID: 24524988
- Phillippi, JA, Green, BR, Eskay, MA, Kotlarczyk, MP, Hill, MR, Robertson, AM, Watkins, SC, Vorp, DA and Gleason, TG. Mechanism of Aortic Medial Matrix Remodeling is Distinct in Bicuspid Aortic Valve Patients. Journal of Thoracic and Cardiovascular Surgery. 2014 Mar;47(3): 1056-64. PMID: 23764410
- Pichamuthu, JE*, Phillippi, JA*, Cleary, Deborah, DA, Chew, DW, Hempel, J, Vorp, DA and Gleason, TG. Differential Tensile Strength and Collagen Composition in Ascending Aortic Aneurysms by Aortic Valve Phenotype. Annals of Thoracic Surgery. 2013 Dec;96 (6): 2147-54. PMID: 24021768 *Equal contribution.
- Tsamis, A, Phillippi, JA, Koch, RG, Pasta, S, DÂ’Amore, A, Watkins, SC, Wagner, W, Gleason, TG and Vorp, DA. Fiber Micro-Architecture in the Longitudinal-Radial and Circumferential-Radial Planes of Ascending Thoracic Aortic Aneurysm Media. Journal of Biomechanics. 2013 Nov 15;46(16):2787-94. PMID: 4075403
- Pasta, S, Phillippi, JA, Gleason, TG and Vorp, DA. The Effect of Aneurysm on the Mechanical Dissection Properties of Human Ascending Thoracic Aorta. Journal of Thoracic and Cardiovascular Surgery. 2012;143(2):460-7. PMID: 21868041
- Phillippi, JA, Eskay, MA, Kubala, AA, Pitt, BR and Gleason, TG. Altered Oxidative Stress Response and Increased Type I Collagen Expression in Bicuspid Aortic Valve Patients. Annals of Thoracic Surgery. 2010 Dec;90(6):1893-8. PMID: 21095332
- Phillippi, JA, Klyachko, EA, Kenny IV JP, Eskay, MA, Gorman. RC and Gleason, TG. Basal and Oxidative Stress-Induced Expression of Metallothionein is Decreased in Ascending Aortic Aneurysms of Bicuspid Aortic Valve Patients. Circulation. 2009 May 12;9(18):2498-2506. PMID: 19398671
- Phillippi, JA, Miller, ED, Weiss, LE, Huard, J, Waggoner, A, and Campbell, P. Microenvironments Engineered by Inkjet Printing Spatially Direct Adult Stem Cells towards Muscle- and Bone-Like Subpopulations. Stem Cells. 2008 Jan;26(1):127-134. PMID: 17901398
- Gleason TG. Aortic Root Replacement with a Composite Valved Conduit. Operative Techniques in Thoracic and Cardiovascular Surgery. Fall 2008;13(3):161-71.
- Gleason TG. Thoracic aortic stent grafting: Is it ready for prime time? Journal of Thoracic and Cardiovascular Surgery. 2006 Jan;131(2):502-3. PMID: 16399288
- Bowen FW, Civan J, Orlin A, Gleason TG. Management of type A aortic dissection and a large pheochromocytoma: a surgical dilemma. Annals of Thoracic Surgery. 2006 Jun; 81(6):2296-8. PMID: 16731177
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