McGowan Institute for Regenerative Medicine affiliated faculty members who are also members of the Pittsburgh Liver Research Center (PLRC) recently published several articles. The authors include:
- Andrew Duncan, PhD, Associate Professor in the Department of Pathology at the University of Pittsburgh with a secondary appointment in the Department of Bioengineering of the Swanson School of Engineering at Pitt
- Satdarshan Paul Monga, MD, Endowed Research Chair in Experimental Pathology and Vice-Chair of Experimental Pathology, Department of Pathology at the University of Pittsburgh, Professor of Pathology (Division of Experimental Pathology), Professor of Medicine (Division of Gastroenterology, Hepatology & Nutrition), and Founding Director of the NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-funded PLRC
- Michael Oertel, PhD, Assistant Professor of Pathology, Division of Experimental Pathology, Department of Pathology
The papers include:
Scaffolding protein IQGAP1 is dispensable but its overexpression promotes hepatocellular carcinoma via YAP1 signaling. Delgado ER, Erickson HL, Tao J, Monga SP, Duncan AW, Anakk S. Molecular and Cellular Biology, 2021 Feb 1;MCB.00596-20.
Nrf2 and β-catenin coactivation in hepatocellular cancer: biological and therapeutic implications. Tao J, Krutsenko Y, Moghe A, Singh S, Poddar M, Bell A, Oertel M, Singhi AD, Geller D, Chen X, Lujambio A, Liu S, Monga SP. Hepatology, 2021 Feb 2.
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O’Donnell CP, Finkel T, Chen BB, Mallampalli RK. Nature Chemical Biology, 2021 Jan 25.
Illustration: Healthy liver. NIH/NIDDK.