Newsletter 2017

December 2017 | VOL. 16, NO. 12| www.McGowan.pitt.edu

Pittsburgh Business Times Recognizes the McGowan Institute and Affiliated Faculty for Innovative Achievements

Western Pennsylvania has long been a hub for innovation. This year the Pittsburgh Business Times (PBT) introduced its Innovation Awards, a program that recognizes those that made extraordinary advances in their respective fields, challenging conventional thinking. They are the disruptors, creating new products and developing new approaches that challenge traditional approaches.  The McGowan Institute for Regenerative Medicine was selected as one of the winners of this inaugural award for its pioneering development and clinical implementation of regenerative medicine-based therapies.  Also, the Human Engineering Research Laboratory under the leadership of McGowan Institute affiliated faculty member Rory Cooper, PhD, was recognized for the development of the PneuChair (TM) pneumatic wheelchair as a PBT Innovation Award winner. The third awardee that has a McGowan Institute relationship is Qrono, Inc.  This Pittsburgh start-up was formed by McGowan Institute faculty member Steven Little, PhD, and his former graduate student Sam Rothstein, PhD.

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November 2017 | VOL. 16, NO. 11| www.McGowan.pitt.edu

As We Celebrate Thanksgiving, Let Us Extend Our Thanks…

• To the 240+ scientists, engineers and clinicians that are the teams of professionals who are committed to the development and translation of regenerative medicine and medical device-based therapies;
• To the dedicated support staffs who make it possible for the scientists, engineers and clinicians to pursue the goals and objectives of the Institute;
• To the hundreds of student trainees who are learning the fundamentals and developing the applications that continue to make regenerative medicine the promise of the future in improved health care and quality of life;
• To the many agencies, foundations, companies, and individual donors without whose fiscal support and encouragement the outcomes that we give thanks for would not have been possible, and;
• To the many patients who have trusted our teams. These individuals are the true pioneers and the heart of the achievements we recognize.

Since the formation of the McGowan Center for Artificial Organ Development (1992) and the McGowan Institute for Regenerative Medicine (2001) there have been many accomplishments advancing the science and clinical achievements in regenerative medicine-based therapies. We see progress in the areas of medical devices, tissue engineering and cell-based therapies, and the prospects for the future are many.  Thanks for the opportunities and outcomes created by all who participate in or support the initiatives of the McGowan Institute.  Best wishes for another successful year!

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October 2017 | VOL. 16, NO. 10| www.McGowan.pitt.edu

An Engineer’s Guide to the Embryo

In roughly 48 hours, the single cell of the fertilized frog egg will undergo dramatic change to develop vital body parts like muscles, a skeleton, eyes, a heart, and a tadpole tail. Scientists have been studying this process to better understand human development, birth defects, and cancer and to advance technologies like organoid generation and cell replacement therapy. Scientists can disrupt embryo development, pause it, and accelerate it; however, they can’t exactly explain how development works. Supported by the National Institutes of Health (NIH), bioengineers at the University of Pittsburgh are taking a crack at understanding what is going on inside the egg.

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September 2017 | VOL. 16, NO. 9| www.McGowan.pitt.edu

Findings About Immune System Could Stop Allergic Skin Reactions at the Cellular Source

Recently reported by PittWire, many people have suffered through an itchy skin rash after a brush with poison oak, wearing jewelry containing nickel, or using latex gloves.

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August 2017 | VOL. 16, NO. 8| www.McGowan.pitt.edu

Dr. Julie Phillippi Receives 5-year, $1.9 Million NIH R01 Award

McGowan Institute for Regenerative Medicine affiliated faculty member Julie Phillippi, PhD, Assistant Professor in the Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, received NIH funding for her project entitled “Matrix mediated vasa vasorum dysfunction in thoracic aortic disease.”  The funding period is August 2017 through June 2022.  The total award is $1,901,221.

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July 2017 | VOL. 16, NO. 7| www.McGowan.pitt.edu

Nanoscale Forces Measured in Aortic Smooth Muscle Cells Tell Story of Disease

Researchers from Virginia Tech and the University of Pittsburgh have collaborated to employ a novel nanoscale fibrous system that can measure the tiny forces exerted by and upon individual cells with extreme precision. The team hopes that this platform, which investigators call nanonet force microscopy (NFM), will provide new knowledge about smooth muscle cell biology that could have implications for treating cardiovascular disease, which is still a leading cause of death in the United States.

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June 2017 | VOL. 16, NO. 6| www.McGowan.pitt.edu

Drag reducing polymers decrease hepatic injury and metastases

The work of McGowan Institute for Regenerative Medicine faculty member Marina Kameneva, PhD, Research Professor of Surgery at the University of Pittsburgh School of Medicine, Professor of Bioengineering, University of Pittsburgh, and Director of the Artificial Blood Program at the McGowan Institute, and colleagues recently appeared in the May 31, 2017, online issue of the publication, Oncotarget.  Co-authors on the paper are Samer Tohme, Hamza O. Yazdani, Vikas Sud, Julie Goswami, Patricia Loughran, Hai Huang Richard L. Simmons, and Allan Tsung, all of the University of Pittsburgh.

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May 2017 | VOL. 16, NO. 5| www.McGowan.pitt.edu

Precision Medicine Improves Treatment Outcomes for Some Pancreatic Cancer Patients

University of Pittsburgh and UPMC researchers are paving the way for genome-targeted treatments in pancreatic cancer, an especially deadly form of cancer with few existing therapeutic options, according to a pair of recent studies.

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April 2017 | VOL. 16, NO. 4| www.McGowan.pitt.edu

McGowan Institute Affiliated Faculty Members Receive CSC Awards for Excellence

The Carnegie Science Center established the Carnegie Science Awards program in 1997 to recognize and promote outstanding science and technology achievements in western Pennsylvania. The Carnegie Science Awards have honored the accomplishments of more than 500 individuals and organizations whose contributions in the fields of science, technology, and education have impacted our region’s industrial, academic, and environmental vitality.

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March 2017 | VOL. 16, NO. 3| www.McGowan.pitt.edu

McGowan Institute for Regenerative Medicine Holds Its Annual Scientific Retreat

The McGowan Institute for Regenerative Medicine held its 2017 Scientific Retreat on March 5-7, 2017. The retreat provided many opportunities to explore collaborative endeavors with other researchers, participating guests, and external partners who are working to bring regenerative medicine technologies to clinical use. The 2017 Retreat program included technical and strategic planning sessions. The program was designed to facilitate insightful discussions and to identify opportunities for partnerships and new initiatives.

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February 2017 | VOL. 16, NO. 2| www.McGowan.pitt.edu

Publication Named a NIEHS Top Paper of 2016

The National Institutes of Health, National Institute of Environmental Health Sciences (NIEHS), recently honored its 2016 Papers of the Year—the top 25 of 2700 publications.  In that elite group, McGowan Institute for Regenerative Medicine faculty member Fabrisia Ambrosio, PhD, MPT, Director of Rehabilitation for UPMC International and an Associate Professor in the Department of Physical Medicine & Rehabilitation at the University of Pittsburgh, and her team were recognized for their paper entitled “Arsenic promotes NF-kB-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function,” published in the journal Stem Cells.  McGowan Institute faculty member Donna Stolz, PhD, Associate Director of the Center for Biologic Imaging, University of Pittsburgh School of Medicine, and an Associate Professor in the Departments of Cell Biology and Pathology at the University of Pittsburgh, is a co-author on the study.

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January 2017 | VOL. 16, NO. 1| www.McGowan.pitt.edu

NIH Award:  Ambulatory Assist Lung for Children

McGowan Institute for Regenerative Medicine faculty members–

• William Federspiel, PhD, William Kepler Whiteford Professor in the Department of Bioengineering with secondary appointments in Chemical Engineering and Critical Care Medicine, and Director of the Medical Devices Laboratory at the McGowan Institute,
• William Wagner, PhD, Director of the McGowan Institute for Regenerative Medicine as well as a Professor of Surgery, Bioengineering and Chemical Engineering at the University of Pittsburgh, and
• Peter Wearden, MD, PhD, congenital cardiothoracic surgeon and Department Chair, Division of Cardiovascular Surgery, Department of Cardiovascular Services at the Nemours Children’s Health System, Orlando, Florida–

are the principal investigators on a recently funded R01 grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health entitled “Ambulatory Assist Lung for Children.”

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