Co Investigator Pamela Moalli and Steven Abramowitch
Title Macrophage Phenotype as a Determinant of Outcome in Pelvic Organ Prolapse Repair
Grant of the Month 2013
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | December 1, 2013
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | November 1, 2013
Co Investigator Donna Stolz, PhD
Title Mechanisms of arsenic-induced muscle morbidity and reduced regenerative capacity
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | October 1, 2013
Title Strategy for enhance mentor replacement of hypodermis to improve skin quality influencing dermal components for improving the quality of skin after acute burn debridement
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | September 1, 2013
Co Investigator Gorantla, Solari, Maul, Vodovotz
Title Ex-Vivo Machine Perfusion with a Novel Oxygen Carrier System to enhance graft preservation and immunologic outcomes
Description: This study will reproduce our initial successful experience with livers in a very challenging transplant model (9 hours of cold ischemia time – CIT). The CTA will be preserved under these new conditions (machine perfusion with a HBOC solution) and compared to the current standard of care. This study is specifically designed to improve the functionality of the CTA tissues (e.g. muscular, neural) after transplantation. The central hypothesis is to demonstrate the benefits of full tissue perfusion and oxygenation during the graft preservation period.
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | August 1, 2013
Project Coordinator Neill Turner
Co Investigator Michel Modo
Title Studies to Evaluate the Effect of Processing Methods upon UBM-ECM
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | July 1, 2013
Title Evaluation of MatriStem as a Vascular Patch for Treatment of Hypoplastic Left Heart Syndrome
Description: Commercially available UBM device will be used for aortic reconstruction to improve outcomes and avoid complications of the currently used material in the Norwood Procedure.
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | June 1, 2013
Co-PI Norm Ducharme
Title An Exploratory Study into the Practical Application of a Regenerative Medicine Approach to Reconstruction of the Equine Upper Airway
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | May 1, 2013
Co-PI Dr. Mark Fleming; Ian Valerio, MD; Benjamin Potter, MD; Jorg Gerlach, MD, PhD; Michael Boninger, MD
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | April 1, 2013
Co-PI Walter Schneider, PhD
Title High Definition Fiber Tracking Biological Diagnosis of TBI Providing Actionable Clinical Report of Quantified Damage
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | March 1, 2013
Collaborator William R. Wagner, PhD
Title Structure-Function Controlled Scaffolds for Improved Soft Tissue Remodeling
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | February 1, 2013
Co-PI Greg Burgreen, PhD
Title Paracorporeal Ambulatory Assist Lung (PAAL)
Summary: Acute and chronic diseases of the lung remain major healthcare problems. Each year nearly 350,000 Americans die of some form of lung disease. Mechanical ventilation provides short-term support for these patients, but longer term support can lead to barotrauma, volutrauma, and other iatrogenic injuries, further exacerbating the respiratory insufficiency. Extracorporeal membrane oxygenation (ECMO) can provide longer term respiratory support but is complex and significantly limits a patient’s mobility. This project will develop a compact respiratory assist device, the Paracorporeal Ambulatory Assist Lung (PAAL), to replace ECMO as a bridge to transplant or recovery in patients with acute and chronic lung failure. The PAAL is a fully integrated blood pump and gas exchange module and is designed for peripheral cannulation (e.g. jugular to femoral) or central cannulation (e.g. right atrium to pulmonary artery and worn on a holster or vest. The PAAL will be designed for longer-term respiratory support (1-3 months before change-out) at 70-100% of normal metabolic requirements, while pumping blood from 2 to 3.5 Liters/min. The specific aims of project are 1) To optimize the design and operational parameters of the PAAL to meet requirements for blood pumping, gas exchange, priming volume, and form factor; 2) To build PAAL prototypes along the design development pathway for bench characterization studies; 3) To improve hemocompatibility of the PAAL by exploring novel molecular Zwitterionic coatings; and 4) To perform acute and chronic animal studies in healthy sheep to demonstrate the in-vivo performance and hemocompatibility of the PAAL device and its interaction with the cardiopulmonary system.
By The McGowan Institute For Regenerative Medicine | Grant of the Month 2013, Grant of the Month | January 1, 2013
Co-PI William Wagner and J. Peter Rubin
Title Autologous Stem Cell-Based Tissue Engineered Vascular Grafts