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Grant of the Month 2013

Grant of the Month
Media Grant of the Month 2013

Grant of the Month | December 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | December 1, 2013
PI Bryan Brown

Co Investigator Pamela Moalli and Steven Abramowitch

Title Macrophage Phenotype as a Determinant of Outcome in Pelvic Organ Prolapse Repair

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Grant of the Month | November 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | November 1, 2013
PI Fabrisia Ambrosio, PhD, PT and Aaron Barchowsky, PhD

Co Investigator Donna Stolz, PhD

Title Mechanisms of arsenic-induced muscle morbidity and reduced regenerative capacity

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Grant of the Month | October 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | October 1, 2013
PI Spencer Brown

Title Strategy for enhance mentor replacement of hypodermis to improve skin quality influencing dermal components for improving the quality of skin after acute burn debridement

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Grant of the Month | September 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | September 1, 2013
PI Paulo Fontes

Co Investigator Gorantla, Solari, Maul, Vodovotz

Title Ex-Vivo Machine Perfusion with a Novel Oxygen Carrier System to enhance graft preservation and immunologic outcomes
Description: This study will reproduce our initial successful experience with livers in a very challenging transplant model (9 hours of cold ischemia time – CIT). The CTA will be preserved under these new conditions (machine perfusion with a HBOC solution) and compared to the current standard of care. This study is specifically designed to improve the functionality of the CTA tissues (e.g. muscular, neural) after transplantation. The central hypothesis is to demonstrate the benefits of full tissue perfusion and oxygenation during the graft preservation period.

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Grant of the Month | August 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | August 1, 2013
PI Stephen F. Badylak

Project Coordinator Neill Turner

Co Investigator Michel Modo

Title Studies to Evaluate the Effect of Processing Methods upon UBM-ECM

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Grant of the Month | July 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | July 1, 2013
PI Peter Wearden

Title Evaluation of MatriStem as a Vascular Patch for Treatment of Hypoplastic Left Heart Syndrome

Description: Commercially available UBM device will be used for aortic reconstruction to improve outcomes and avoid complications of the currently used material in the Norwood Procedure.

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Grant of the Month | June 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | June 1, 2013
PI Bryan Brown

Co-PI Norm Ducharme

Title An Exploratory Study into the Practical Application of a Regenerative Medicine Approach to Reconstruction of the Equine Upper Airway

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Grant of the Month | May 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | May 1, 2013
PI J. Peter Rubin, MD

Co-PI Dr. Mark Fleming; Ian Valerio, MD; Benjamin Potter, MD; Jorg Gerlach, MD, PhD; Michael Boninger, MD

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Grant of the Month | April 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | April 1, 2013
PI David O. Okonkwo, MD, PhD

Co-PI Walter Schneider, PhD

Title High Definition Fiber Tracking Biological Diagnosis of TBI Providing Actionable Clinical Report of Quantified Damage

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Grant of the Month | March 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | March 1, 2013
PI Antonio D’Amore, PhD

Collaborator William R. Wagner, PhD

Title Structure-Function Controlled Scaffolds for Improved Soft Tissue Remodeling

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Grant of the Month | February 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | February 1, 2013
PI William Federspiel, PhD, William R. Wagner, PhD , Christian A. Bermudez, MD, James Antaki, PhD

Co-PI Greg Burgreen, PhD

Title Paracorporeal Ambulatory Assist Lung (PAAL)

Summary: Acute and chronic diseases of the lung remain major healthcare problems. Each year nearly 350,000 Americans die of some form of lung disease. Mechanical ventilation provides short-term support for these patients, but longer term support can lead to barotrauma, volutrauma, and other iatrogenic injuries, further exacerbating the respiratory insufficiency. Extracorporeal membrane oxygenation (ECMO) can provide longer term respiratory support but is complex and significantly limits a patient’s mobility. This project will develop a compact respiratory assist device, the Paracorporeal Ambulatory Assist Lung (PAAL), to replace ECMO as a bridge to transplant or recovery in patients with acute and chronic lung failure. The PAAL is a fully integrated blood pump and gas exchange module and is designed for peripheral cannulation (e.g. jugular to femoral) or central cannulation (e.g. right atrium to pulmonary artery and worn on a holster or vest. The PAAL will be designed for longer-term respiratory support (1-3 months before change-out) at 70-100% of normal metabolic requirements, while pumping blood from 2 to 3.5 Liters/min. The specific aims of project are 1) To optimize the design and operational parameters of the PAAL to meet requirements for blood pumping, gas exchange, priming volume, and form factor; 2) To build PAAL prototypes along the design development pathway for bench characterization studies; 3) To improve hemocompatibility of the PAAL by exploring novel molecular Zwitterionic coatings; and 4) To perform acute and chronic animal studies in healthy sheep to demonstrate the in-vivo performance and hemocompatibility of the PAAL device and its interaction with the cardiopulmonary system.

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Grant of the Month | January 2013

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2013 | January 1, 2013
PI David A. Vorp

Co-PI William Wagner and J. Peter Rubin

Title Autologous Stem Cell-Based Tissue Engineered Vascular Grafts

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  • Home
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  • About Us
    • Welcome
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    • What Is Regenerative Medicine?
    • Executive Committee
    • Contact Us
    • Clinical Site
  • Our Research
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      • Tissue Engineering and Biomaterials
      • Cellular Therapies
      • Medical Devices and Artificial Organs
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    • Clinical Trials
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  • Media
    • Current News
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    • Grant of the Month
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  • Professional Development
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    • CATER
    • Post-Doctoral Opportunities
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    • Wiegand Summer Internship
    • Admissions
    • Summer School
    • 2021 Scientific Retreat
    • Human Performance Optimization Conference
Regenerative Medicine at the McGowan Institute