PI Fabrisia Ambrosio, PhD, PT and Aaron Barchowsky, PhD

Co Investigator Donna Stolz, PhD

Title Mechanisms of arsenic-induced muscle morbidity and reduced regenerative capacity

Description: Environmental toxicants, such as arsenic in drinking water, pose a significant risk for causing skeletal muscle myopathies, atrophy and reduced regenerative capacity; processes that are among the greatest factors contributing to declines in functional mobility and strong predictors of mortality. The negative impact of chronic exposure to arsenic on muscle metabolism and stem cell biology represents important pathogenic mechanisms for reducing the capacity to maintain, regenerate, and repair muscle. Advancing the mechanistic understanding of arsenic effects on muscle maintenance, stem cells, and healing capacity in the etiology of arsenic-induced muscle weakness and fatigue will aid in the design of strategies for improving outcomes in patients in arsenic endemic areas and increasing basic knowledge of mechanisms through which environmental exposures impair stem cell function.

Source: National Institute for Environmental Health and Safety: 1R01 ES023696-01

Term 12/01/2013 – 11/30/2018

Amount $2,349,370