Biomarkers That Can Provide Advance Warning of Deadly Kidney Condition in Critically Ill Patients Identified
A national, multi-center study led by McGowan Institute for Regenerative Medicine affiliated faculty member and senior investigator John Kellum, MD, a Critical Care Physician at UPMC and Director of the Pitt Center for Critical Care Nephrology, found biomarkers that can tell a physician if a patient is at risk for acute kidney injury (AKI), a condition that often affects those in intensive care and can occur hours to days after serious infections, surgery, or taking certain medications.
The results, now available in the American Journal of Respiratory and Critical Care Medicine, validates previous research from this group identifying the biomarkers, known as tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP-7) in urine, that signal the kidneys are stressed and at risk for failing. The biomarkers are indicators of cell damage, a key component in the onset of AKI.
“AKI remains one of the most common complications among critically ill patients, affecting up to 7 percent of all hospitalized patients, yet we lack a precise and reliable method of discerning risk,” said Dr. Kellum. “By providing actionable information, this study advances the translation of biomarker technology into routine practice.”
Investigators enrolled 420 critically ill patients. The primary analysis assessed the ability of the biomarkers to predict moderate to severe AKI within 12 hours of test measurement. To confirm the findings, a committee of three independent expert nephrologists who were blinded to the results of the test reviewed the cases to diagnose AKI.
AKI is asymptomatic, lacking warning signs such as pain, shortness of breath, or other clinical symptoms, particularly in the early stages when intervention is most beneficial. The incidence of AKI is high among critically ill patients, with up to 50 percent developing some degree of AKI during their illness, increasing the risk of death due to kidney failure.
“This new study confirms these findings using an expert panel to adjudicate AKI—the first ever to do so for this disease,” said Dr. Kellum.
Abstract (Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication. JA Kellum, et al. American Journal of Respiratory and Critical Care Medicine; online 02/21/14.)