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Grant of the Month2022-05-27T13:44:45+00:00

Grant of the Month

  • Grant of the Month | November 2021

    Categories: Grant of the Month, Grant of the Month 2021Published On: November 23, 2021

    Program Director: James Luketich Co-PDs: Julie Phillippi and David Vorp Title: Cardiothoracic Surgery Research Training Program Description: This application is for a research training grant focused on training the next generation of academic cardiac and thoracic surgeons. Given the current and future shortage of cardiothoracic surgeons, the extremely diverse clinical activities, and broad array of conditions treated by cardiac and thoracic surgeons, an NIH T32 training program in cardiothoracic surgery is an emergent unmet need to improve the cardiothoracic surgical workforce. The necessary resources to support this mission is largely dictated by the capacity for initial research training mid-way through [...]

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  • Grant of the Month | October 2021

    Categories: Grant of the Month, Grant of the Month 2021Published On: October 28, 2021

    PI: Andrew Duncan Title: Mechanisms of Liver Regeneration Induced by Acetaminophen Toxicity Description: Liver disorders affect 30 million people in the United States and are the country’s 10th leading cause of death. To improve liver disease treatments, a better understanding of hepatocyte biology is required. The liver contains diploid and polyploid hepatocytes, with polyploids comprising nearly 50% adult human and 90% adult mouse hepatocytes. The functional differences between diploid and polyploid hepatocytes are poorly understood. We previously demonstrated that diploid hepatocytes facilitate rapid liver regeneration, but it remains unknown how diploid and polyploid hepatocytes respond to drug-induced injury. Acetaminophen (APAP) [...]

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  • Grant of the Month | September 2021

    Categories: Grant of the Month, Grant of the Month 2021Published On: September 29, 2021

    PI: Alisse Hauspurg Co-I: Ramakrishna Mukkamala, Sanjeev Shroff, and Aman Mahajan Title: Development of a smartphone-based device to detect fluid overload among postpartum women with hypertensive disorders of pregnancy Description: Hypertensive disorders of pregnancy contribute to a significant proportion of maternal morbidity and mortality and are the most common reason for hospital readmission postpartum. While treatment of hypertension is the cornerstone of postpartum management, emerging evidence suggests that implementation of robust remote blood pressure monitoring and treatment programs alone do not reduce maternal morbidity or hospital readmissions related to postpartum fluid overload and heart failure symptoms. The ability to predict [...]

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  • Grant of the Month | August 2021

    Categories: Grant of the Month, Grant of the Month 2021Published On: August 30, 2021

    PI: Mo Ebrahimkhani and Samira Kiani Title: Collaborative Research: RECODE: Directed Differentiation of Human Liver Organoids via Computational Analysis and Engineering of Gene Regulatory Networks Description: Organoids are group of cells produced from stem cells that mimic closely structure and functions of human organs. Organoids can be used for modeling the development of human diseases and for testing newly produced medicines. However, there is a need for generation of human organoids with better function and less variability. This project aims to use genetic based analysis and engineering to control stem cell differentiation towards human liver cells and improve the final manufacturing [...]

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  • Grant of the Month | July 2021

    Categories: Grant of the Month, Grant of the Month 2021Published On: July 29, 2021

    PI: Kacey Marra Title: Development of an Implantable Medical Device for Human Extremity Nerve Injuries Description: Arm, leg, and nerve-related injuries are among the most common injuries sustained by our brave Warfighters. Battlefield extremity injuries are often more severe than civilian, thus highlighting a need for therapies that treat extensive peripheral nerve injuries. Most challenging of these are the healing of long-gap peripheral nerve injuries (i.e., nerve gaps greater than 1 inch). When there is a long-gap nerve injury, the current solution is to relocate a nerve from one part of the body to where the nerve gap exists, a surgical [...]

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  • Grant of the Month | June 2021

    Categories: Grant of the Month, Grant of the Month 2021Published On: June 30, 2021

    PI: William Wagner Co-PI: John Alcorn, Stephen Badylak,  Louis Falo, William Federspiel, Neeraj Gandhi, Eric Lagasse, Steven Little, Alan Wells, and Cecilia Yates Title: Therapies for COVID-related Disease and Technology Development Description: Since December 2020, the FDA (Federal Drug Administration) emergency use authorization of two vaccines directed against SARS-CoV-2 (COVID 19 or Coronavirus) has changed the trajectory and future of personal and public health management of COVID-19. While these vaccines show success rates as high as 95% in preventing severe COVID-19 adverse events, these vaccine studies did not investigate the efficacy of these vaccines in the context of a patient receiving [...]

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  • Grant of the Month | May 2021

    Categories: Grant of the Month, Grant of the Month 2021Published On: May 25, 2021

    PI: William Federspiel / Ryan Orizondo Title: Omniphobic coating of extracorporeal life support systems for improved thromboresistance (Subaward) Description: The goal of this work is to use an omniphobic tethered liquid perfluorocarbon (TLP) coating to develop a highly thromboresistant oxygenator. Such a device would diminish the need for systemic anticoagulants during extracorporeal membrane oxygenation and potentially reduce treatment complications due to both bleeding and thrombosis. The bilayer TLP coating is composed of a thin liquid perfluorocarbon (PFC) film atop of a molecular PFC layer that is covalently bound to the material surface. This specific proposal will focus on the optimization [...]

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  • Grant of the Month | April 2021

    Categories: Grant of the Month, Grant of the Month 2021Published On: April 30, 2021

    PI: Louis Falo Title: Engineering the Skin Immune System to Induce Systemic Immune Responses Description: The skin functions as a potent immune organ, rendering the readily accessible cutaneous microenvironment an attractive target that can be locally engineered to induce and regulate systemic immune responses. Increasing age is associated with changes in immune function (immunosenescence) that result in increased susceptibility to diseases and poor vaccine responses in older adults. This proposal is designed to bring together very recent and significant advances in dermatology and skin biology to address critical problems in human health. Here, we specifically focus on the skin microenvironment [...]

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