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Grant of the Month

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Home Media Grant of the Month

Grant of the Month | April 2022

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2022 | Comments are Closed | 27 April, 2022 | 0

PI: Donghun Shin

Title: Delineating the molecular mechanisms of hepatocyte-to-cholangiocyte reprogramming Read More

Grant of the Month | March 2022

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2022 | Comments are Closed | 25 March, 2022 | 0

PI: Sruti Shiva

Co-PI: Anthony J. Molina

Title: The relationship between blood based bioenergetics and muscle function, mobility, and aging Read More

Grant of the Month | February 2022

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2022 | Comments are Closed | 24 February, 2022 | 0

PI: Kang Kim

Title: Super Resolution Ultrasound Imaging of Vasa Vasorum to Characterize the Progression of Atherosclerotic Plaques and Predict Rupture Vulnerability Read More

Grant of the Month | January 2022

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2022 | Comments are Closed | 28 January, 2022 | 0

PI: Jonathan Vande Geest

Title: Preclinical Assessment of a Compliance Matched Biopolymer Vascular Graft Read More

Grant of the Month | December 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 14 December, 2021 | 0

PIs: Pamela Moalli, Kyle Orwig, and Caroline Gargett

Title: Vaginal Stem Cells: The Missing Link in Vaginal Reconstruction Read More

Grant of the Month | November 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 23 November, 2021 | 0

Program Director: James Luketich

Co-PDs: Julie Phillippi and David Vorp

Title: Cardiothoracic Surgery Research Training Program Read More

Grant of the Month | October 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 28 October, 2021 | 0

PI: Andrew Duncan

Title: Mechanisms of Liver Regeneration Induced by Acetaminophen Toxicity

Description: Liver disorders affect 30 million people in the United States and are the country’s 10th leading cause of death. To improve liver disease treatments, a better understanding of hepatocyte biology is required. The liver contains diploid and polyploid hepatocytes, with polyploids comprising nearly 50% adult human and 90% adult mouse hepatocytes. The functional differences between diploid and polyploid hepatocytes are poorly understood. We previously demonstrated that diploid hepatocytes facilitate rapid liver regeneration, but it remains unknown how diploid and polyploid hepatocytes respond to drug-induced injury. Acetaminophen (APAP) is a common analgesic that can cause acute liver injury, resulting in liver failure and death when taken in excess. When APAP overdose causes extensive centrilobular hepatocyte death, the liver undergoes compensatory proliferation and recovers if the ratio of necrosis to regeneration is low. To investigate the role diploid and polyploid hepatocytes in vivo, we utilize E2f7 and E2f8 liver-specific knockout mice (LKO) where E2f7 and E2f8 are deleted during postnatal development; these mice are functionally normal through 6-9 months of age but are depleted of polyploid hepatocytes (LKO livers are >70% diploid). Preliminary studies indicate that LKO mice enriched with diploid hepatocytes are less damaged and recover faster from APAP injury than wild-type (WT) mice enriched with polyploid hepatocytes. The Grantee shall investigate mechanisms of liver injury and regeneration during APAP-induced liver injury and failure. This project shall determine ploidy-dependent and ploidy-independent mechanisms of liver repair and regeneration following APAP overdose. Read More

Grant of the Month | September 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 29 September, 2021 | 0

PI: Alisse Hauspurg

Co-I: Ramakrishna Mukkamala, Sanjeev Shroff, and Aman Mahajan

Title: Development of a smartphone-based device to detect fluid overload among postpartum women with hypertensive disorders of pregnancy Read More

Grant of the Month | August 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 30 August, 2021 | 0

PI: Mo Ebrahimkhani and Samira Kiani

Title: Collaborative Research: RECODE: Directed Differentiation of Human Liver Organoids via Computational Analysis and Engineering of Gene Regulatory Networks Read More

Grant of the Month | July 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 29 July, 2021 | 0

PI: Kacey Marra

Title: Development of an Implantable Medical Device for Human Extremity Nerve Injuries Read More

Grant of the Month | June 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 30 June, 2021 | 0

PI: William Wagner

Co-PI: John Alcorn, Stephen Badylak,  Louis Falo, William Federspiel, Neeraj Gandhi, Eric Lagasse, Steven Little, Alan Wells, and Cecilia Yates Read More

Grant of the Month | May 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 25 May, 2021 | 0

PI: William Federspiel / Ryan Orizondo

Title: Omniphobic coating of extracorporeal life support systems for improved thromboresistance (Subaward) Read More

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