• Pitt
  • Health Sciences
  • UPMC
Regenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan Institute
  • Home
  • Our People
    • Faculty/Staff Bios
    • Core Faculty Publications
    • Administrative Resources
  • Our Technologies
  • About Us
    • Welcome
    • Video
    • Mission Statement
    • What Is Regenerative Medicine?
    • Executive Committee
    • Contact Us
    • Clinical Site
  • Our Research
    • Focus Areas
      • Tissue Engineering and Biomaterials
      • Cellular Therapies
      • Medical Devices and Artificial Organs
      • Clinical Translation
    • Matrix
    • Centers
    • Laboratories
    • Clinical Trials
    • Initiatives
  • Media
    • Current News
    • News Archive
    • Video
    • Podcasts
    • Newsletter
    • Grant of the Month
    • Publication of the Month
    • Media Contact
    • Video Links
  • Professional Development
    • Seminar Series
    • Special Events
    • Student Interest Groups
    • CATER
    • Post-Doctoral Opportunities
    • Career Opportunities
    • Wiegand Summer Internship
    • Admissions
    • Summer School
    • 2021 Scientific Retreat

Grant of the Month

  • Podcasts
  • News Archive
    • Cellular Therapy
  • Current News
  • Media Contact
  • Newsletter
  • Grant of the Month
  • Publication of the Month
  • Categories
  • Video Links
Home Media Grant of the Month

Grant of the Month | March 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 26 March, 2021 | 0

PI: Alejandro Almarza

Co-PI: Juan Taboas

Title: Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration Read More

Grant of the Month | February 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 24 February, 2021 | 0

PI: George Michalopoulos

Title: Inhibition of EGF Receptor Prevents and Reverses Non-Alcoholic Fatty Liver Disease Read More

Grant of the Month | January 2021

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2021 | Comments are Closed | 29 January, 2021 | 0

PI: William R. Wagner

Title: Support for Proof-of-Concept Studies in Regenerative Medicine

Description: This proposal provides support for proof-of concept studies for advancing the state-of-the-art in regenerative medicine. Successful studies will be positioned to compete for advanced studies with funding from Federal agencies. The proposal includes projects involving both clinical and academic researchers all of whom are active in the growing field of Regenerative Medicine. Read More

Grant of the Month | December 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 18 December, 2020 | 0

PIs: David Vorp

Title: Preclinical Optimization and Design for Manufacturability of Immunoregulatory Tissue-Engineered Vascular Graft Read More

Grant of the Month |November 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 25 November, 2020 | 0

PIs: Piervincenzo Rizzo

Co-PIs: Samuel Dickerson, Ian Sigal, Ian Conner, and Robert Handzel

Title: Managing Glaucoma in the Digital Age: A New Tonometer to Connect Patients to their Caregivers Read More

Grant of the Month |October 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 26 October, 2020 | 0

PIs: D. Lansing Taylor, Jaideep Behari, and Alejandro Soto-Guttierrez

Title: A Vascularized Patient-Derived iPSC Liver Acinus Microphysiological System as an Innovative Precision Medicine Platform for Optimizing Clinical Trial Design for Nonalcoholic Fatty Liver Disease Read More

Grant of the Month |September 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 30 September, 2020 | 0

PIs: David H. Kohn, William V. Giannobile, David J. Mooney, Charles Sfeir, and William R. Wagner

Title: Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center: Advancing Dental, Oral, and Craniofacial Regeneration to Clinical Trial Initiation Read More

Grant of the Month |August 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 27 August, 2020 | 0

PI: George Gittes

Title: Alpha Cells Conversion to Beta Cells in Non-Human Primates

Description: An ideal solution to the treatment or cure of type 1 diabetes mellitus would be the formation of new functioning β-cells from the patient’s own tissues that are not attacked by the autoimmunity, thereby avoiding the need for any immunosuppression. Abundant recent data have suggested that α-cells are a viable potential source for endogenous transdifferentiation into β-cells. Here, we describe a pancreatic intraductal viral delivery system in the mouse, wherein a single infusion of an adeno-associated virus (AAV), carrying a pdx1/mafA expression vector, is given to a toxin-induced (alloxan) diabetic mouse. This AAV gene therapy induced robust and durable α-cell transdifferentiation into β-cell-like cells through neogenesis, with recovery of over 60% of the β-cell mass within 4 weeks, and with persistent, durable euglycemia. Serendipitously, when this β-cell-like cell neogenesis was similarly induced in the autoimmune NOD mouse model, the mice became euglycemic for 4 months or more, without any additional therapy or immunosuppression. To our knowledge, no clinically applicable β-cell replacement therapy in NOD mice has been successful without immunosuppression. We suspect that the neogenic β-cell-like cells may not be attacked by the autoimmunity because they are “imperfect” β-cells by RNA-seq analysis. Since pancreatic duct injection is routinely performed in humans as a relatively simple, non-surgical procedure, and since numerous viral gene therapy trials are currently ongoing for several diseases, we feel that our approach may be rapidly translatable to humans with type 1 diabetes mellitus. In this proposal, we will perform important proof-of-principle studies in non-human primates as last steps in preparation for human gene therapy clinical trials. The primate pancreas has a very different texture and consistency than the mouse pancreas (and is very similar to the human pancreas). Thus, the mechanics of the viral delivery will likely require substantial alterations. In addition, a glucagon promoter is preferable to the CMV promoter for expression of pdx1 and mafA, so we will strive to develop and optimize a glucagon promoter vector that is effective in primates. Further studies will investigate this pancreatic ductal infusion approach in the context of AAV neutralizing antibodies. We will also perform detailed analyses of the new β-cell-like cells, including physiology, gene expression phenotype, and anatomy. In summary, we feel that the proposed studies, if successful, should position us well in preparation for clinical trials in humans with type 1 diabetes mellitus. Read More

Grant of the Month | July 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 28 July, 2020 | 0

PI: Fabrisia Ambrosio

PI: Thomas Rando

Title: Alliance for Regenerative Rehabilitation Research & Training (AR3T) Read More

Grant of the Month | June 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 24 June, 2020 | 0

PI: David Vorp

Title: The Role of Fibrinolysis in Tissue Engineered Vascular Grafts for Aged Individuals Read More

Grant of the Month | May 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 28 May, 2020 | 0

PI: Anita McElroy

Co-PIs: Paul Duprex and Alan Wells

Title: SARS-CoV-2 clinical and community serosurveillance Read More

Grant of the Month | April 2020

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2020 | Comments are Closed | 26 May, 2020 | 0

PI: Takashi Kozai

Title: CAREER: Uncovering the Impact of Traditional and Novel Chronic Stimulation Modalities on Neural Excitability and Native Neuronal Network Function Read More

123
Print Friendly, PDF & Email

Grant of the Month Archives

  • Grant of the Month 2021 (3)
  • Grant of the Month 2020 (12)
  • Grant of the Month 2019 (12)
  • Grant of the Month 2018 (12)
  • Grant of the Month 2017 (12)
  • Grant of the Month 2016 (12)
  • Grant of the Month 2015 (12)
  • Grant of the Month 2014 (12)
  • Grant of the Month 2013 (12)
  • Grant of the Month 2012 (12)
  • Grant of the Month 2011 (12)
  • Grant of the Month 2010 (12)
  • Grant of the Month 2009 (12)
  • Grant of the Month 2008 (12)
  • Grant of the Month 2007 (12)
  • Grant of the Month 2006 (9)
  • site map
  • links
  • contact
  • subscribe to our newsletter
© Copyright 2021 McGowan Institute for Regenerative Medicine
A program of the University of Pittsburgh and the University of Pittsburgh Medical Center
  • Home
  • Our People
    • Faculty/Staff Bios
    • Core Faculty Publications
    • Administrative Resources
  • Our Technologies
  • About Us
    • Welcome
    • Video
    • Mission Statement
    • What Is Regenerative Medicine?
    • Executive Committee
    • Contact Us
    • Clinical Site
  • Our Research
    • Focus Areas
      • Tissue Engineering and Biomaterials
      • Cellular Therapies
      • Medical Devices and Artificial Organs
      • Clinical Translation
    • Matrix
    • Centers
    • Laboratories
    • Clinical Trials
    • Initiatives
  • Media
    • Current News
    • News Archive
    • Video
    • Podcasts
    • Newsletter
    • Grant of the Month
    • Publication of the Month
    • Media Contact
    • Video Links
  • Professional Development
    • Seminar Series
    • Special Events
    • Student Interest Groups
    • CATER
    • Post-Doctoral Opportunities
    • Career Opportunities
    • Wiegand Summer Internship
    • Admissions
    • Summer School
    • 2021 Scientific Retreat
Regenerative Medicine at the McGowan Institute