PI Peter Wearden

Title Evaluation of MatriStem as a Vascular Patch for Treatment of Hypoplastic Left Heart Syndrome

Description: Commercially available UBM device will be used for aortic reconstruction to improve outcomes and avoid complications of the currently used material in the Norwood Procedure.

Objectives:

  • Evaluate ability of commercially available ECM product to improve function of reconstructed aorta when compared to clinical gold standard.
  • Assess effectiveness of the ECM device to reconstruct a partial circumferential defect and respond with appropriate cell infiltration and mechanical behavior.

Activities:

  • Perform in vitro experimentation to assess and characterize samples for mechanical and histological composition.
  • Perform in vivo implantation of UBM and cryopreserved pulmonary arterial tissue into piglets
  • Measure mechanical characteristics, cellular function, and flow characteristics after implantation
  • Assess host response and remodeling after implantation

Source: ACell, Inc.

Term: 07/01/2013 – 06/30/2014

Amount: Direct Costs: $76,915
Indirect Costs: $35,535
Total Costs: $112,451