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Medical Devices

Home Archive by category "Medical Devices"

Sensing Signals in Paralyzed Muscles

By The McGowan Institute For Regenerative Medicine | Current News, Featured News, Medical Devices | May 5, 2022

For people with tetraplegia—a condition in which all four limbs have lost motor ability—regaining independence is a top priority. Although there is no cure for paralysis caused by neurological disorders, robotic arms and exoskeletons may provide some assistance. Controlling these robotic devices, however, is a complex problem. Researchers have experimented with voice control (which struggles to translate verbal commands into a three-dimensional space), brain-computer interfaces (which require complex surgery), and joysticks (which often mean multiple rounds of positioning for each arm segment). Read More

Upcoming Stentrode Trial in Pittsburgh to Help Patients with Quadriparesis

By The McGowan Institute For Regenerative Medicine | Current News, Featured News, Medical Devices | April 27, 2022

Four paralyzed people in Australia can now operate a computer using only their thoughts thanks to a brain implant developed in part by Carnegie Mellon University’s Douglas Weber, PhD, Professor of Mechanical Engineering and Neuroscience and an affiliated faculty member of the McGowan Institute for Regenerative Medicine. Emily Mullin, Pittsburgh Post-Gazette, recently spoke with Dr. Weber on the status of this brain-computer interface. Read More

EV2 Technologies Takes 2nd Place in 2022 Randall Family Big Idea Competition, Wins $15K Prize

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | April 20, 2022

EV2 Technologies’ Biocarpet is a flexible and fully biodegradable endovascular device that uses a special thermoforming technique and provides treatment of peripheral arterial disease in small arteries and across joints. The team’s approach minimizes vascular wall stress thus reducing restenosis. This technology was developed in the laboratories of the McGowan Institute for Regenerative Medicine and won the $15,000 prize at the 2022 Randall Family Big Idea Competition.  Collaborators on this effort include: Read More

Podcast: A History of Mechanical Circulatory Support of the Heart with Dr. Harvey Borovetz

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | April 13, 2022

After receiving his BA in Physics from Brandeis University in 1969, McGowan Institute for Regenerative Medicine faculty member Harvey Borovetz, PhD, went on to earn an MS and a PhD degree, both in bioengineering, from Carnegie Mellon University in 1973 and 1976, respectively. Today, he is a Distinguished Professor and former Chair (2002-2013) in the Department of Bioengineering, Swanson School of Engineering at the University of Pittsburgh; the Robert L. Hardesty Professor in the Department of Surgery, University of Pittsburgh School of Medicine; a Professor of Chemical and Petroleum Engineering; a Professor in the Clinical and Translational Science Institute; and a University Honors College Faculty Fellow. Dr. Borovetz’s current research interests focus on the design and clinical utilization of cardiovascular organ replacements for both adult and pediatric patients. Read More

Investigating the Effects of Critical Illness in Early Childhood on Neurocognitive Outcomes

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices, Neuroscience | March 16, 2022

Approximately 23,700 children in the U.S. undergo invasive mechanical ventilation for acute respiratory failure annually. Although most survive, little is known if they have worse long-term neurocognitive function than children who do not undergo such procedures. There are concerns about neurotoxic effects of critical illness and its treatment on the developing brain. Therefore, infants and young children may be uniquely susceptible to adverse neurocognitive outcomes after invasive mechanical ventilation. Read More

Dr. William Wagner Points to Bright Future for Regenerative Medicine

By The McGowan Institute For Regenerative Medicine | Cellular Therapy, Computations and Modeling, Current News, Medical Devices, Tissue Engineering | December 8, 2021

The McGowan Institute for Regenerative Medicine has been one of the prolific research centers at the University of Pittsburgh over the past 25 years, particularly in terms of its impact from translating discoveries from the lab to the clinic/market. Read More

Pediatric Device Innovators Forum #5

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | November 23, 2021

A great need currently exists for medical devices designed specifically for children.

Pediatric Device Innovators Forum (PDIF) is a recurring collaborative educational experience designed to connect and foster synergy among innovators across the technology development ecosystem who are interested in pediatric medical device development. Read More

Hemolung Respiratory Assist System Receives FDA De Novo Clearance

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | November 17, 2021

ALung Technologies, Inc., the leading provider of low-flow extracorporeal carbon dioxide removal (ECCO2R) technologies for treating patients with acute respiratory failure, announced that the Food and Drug Administration (FDA) has granted the company De Novo clearance for the Hemolung Respiratory Assist System. This system was developed  at the McGowan Institute for Regenerative Medicine by a team of researchers led by faculty member William Federspiel, PhD, the company’s cofounder and professor of bioengineering, chemical engineering, critical care medicine, and the Clinical Translation Institute at the University of Pittsburgh. Dr. Federspiel is also the director of the Medical Devices Laboratory at the McGowan Institute. Read More

Newly Patented Device Anchored in 50+ Years of Musculoskeletal Research

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices, Musculoskeletal | November 10, 2021

Soft tissue injuries — like rotator cuff tears or hip impingement — are fairly common, particularly among athletes and older populations. These injuries frequently require surgery where multiple suture anchors are inserted into the bone, providing a strong base through which a suture can be threaded to reattach tendons and ligaments. Read More

Using AI to Treat Acute Kidney Injuries

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | October 27, 2021

Among critically ill patients with acute kidney injury and treated with dialysis in the intensive care unit, if one could accurately predict early which patients will develop low blood pressure then effective treatments could be given. In a recently funded study, co-principal investigators McGowan Institute for Regenerative Medicine affiliated faculty member Gilles Clermont, MD, Professor of Critical Care Medicine at the University of Pittsburgh, and Raghavan Murugan, MD, Professor of Critical Care Medicine at Pitt, and their team propose to develop and validate an artificial intelligence system that will predict low blood pressure even before it occurs and recommend correct treatment to clinicians.  McGowan Institute affiliated faculty member Robert Parker, PhD, Professor in the Department of Chemical and Petroleum Engineering at Pitt, is a member of this team that will receive funding for an NIH grant proposal entitled “AI driven acute renal replacement therapy (AID-ART).” The award is for $2.9M and is for 4 years from the National Institute of Diabetes and Digestive and Kidney Diseases. Read More

BRAIN Initiative Funding Received for BCI Development and Testing

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices, Neuroscience | October 20, 2021

A person suffering from amyotrophic lateral sclerosis (ALS) endures the progressive loss of muscle function throughout their body. Eventually, they lose the ability to control their limbs, to swallow, and even to speak. Their inability to communicate becomes a particularly devastating symptom of the illness. Other diseases can cause similar, debilitating impairment. Read More

Researchers Develop Coating for Endotracheal Tubes that Releases Antimicrobial Peptides

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | September 15, 2021

In a proof-of-concept study, researchers led by McGowan Institute for Regenerative Medicine affiliated faculty member Riccardo Gottardi, PhD, Assistant Professor of Pediatrics and head of the Bioengineering and Biomaterials Laboratory at the Children’s Hospital of Philadelphia (CHOP), have created a coating that can be applied to endotracheal tubes and release antimicrobial peptides that target infectious bacteria with specificity. The innovation could reduce upper-airway bacterial inflammation during intubation, a situation that can lead to chronic inflammation and a condition called subglottic stenosis, the narrowing of the airway by an accumulation of scar tissue. The findings were published in the journal The Laryngoscope. Read More

Dr. Tracy Cui Receives Chancellor’s Gap Project Funding

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | September 1, 2021

A sign of the strength of University of Pittsburgh’s innovation and entrepreneurship ecosystem is the reauthorization earlier in 2021 of the Chancellor’s Gap Fund, which provides grants of $25,000 to $75,000 for innovators with promising discoveries to explore the commercial potential of their ideas. Read More

Predicting Complications Postpartum

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | September 1, 2021

A relevant cardiac health trend is the United States’ growing maternal mortality rate — the worst among industrialized countries. The majority of maternal deaths occur postpartum and result from hypertensive disorders like preeclampsia and gestational hypertension. Read More

Dr. Rory Cooper Receives 2021 Seed Grant Funding

By The McGowan Institute For Regenerative Medicine | Current News, Education, Medical Devices | August 25, 2021

This year, 20 projects were selected for 2021 Seed Grant Program, and a project of McGowan Institute for Regenerative Medicine affiliated faculty member Rory Cooper, PhD, FISA and Paralyzed Veterans of America Professor and Distinguished Professor of the Department of Rehabilitation Science & Technology and Founding Director and VA Senior Research Career Scientist of the Human Engineering Research Laboratories, was one of the projects funded. Read More

Divers Have Brain Oxygen Levels Even Lower Than Seals During Deep Dives

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | August 4, 2021

Elite freedivers who dive unaided in open sea, have brain oxygen levels even lower than seals during their deepest dives, new research at the University of St. Andrews has found. Read More

Sense of Touch Improves Control of Robotic Arm

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices, Neuroscience | July 14, 2021

Most able-bodied people take their ability to perform simple daily tasks for granted—when they reach for a warm mug of coffee, they can feel its weight and temperature and adjust their grip accordingly so that no liquid is spilled. People with full sensory and motor control of their arms and hands can feel that they’ve made contact with an object the instant they touch or grasp it, allowing them to start moving or lifting it with confidence. Read More

SURGIMESH Benefits Hernia Patients

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | July 14, 2021

As much as 10% of the population develops some type of hernia during life.1 More than 1 million abdominal hernia repairs are performed each year, with inguinal hernia repairs constituting nearly 800,000 of these cases.2 According to a February 2012 Wall Street Journal article, more than 30% of patients may, unfortunately, suffer from long-term chronic pain and restricted movement after surgery to fix a hernia.3 Read More

Engineering Smarter Stents

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | June 30, 2021

An estimated two million people will need a coronary artery stent every year. A small mesh tube inserted into a narrow or blocked coronary artery, a stent can help ensure blood can continue to flow through the artery unimpeded. Today, many also contain a coating that releases a steady dose of medication to improve healing and keep the blockage from coming back. Read More

Dr. Kenton Gregory to Support Development of AI-Based Applications for Mass Casualty Events

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | June 30, 2021

An earthquake in a major city, a bomb in a subway, a bus crash in rural town, COVID-19 pandemic hot zones — any event that overwhelms the capacity of available health care facilities is considered a mass casualty event. Lung damage and other internal injuries are particularly challenging to diagnose in multiple casualties during these events. Read More

Implantable ‘Living Pharmacy’ Could Control Body’s Sleep/Wake Cycles

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | June 16, 2021

The Defense Advanced Research Projects Agency (DARPA) has funded a cooperative agreement with multiple organizations worth up to $33 million over four-and-a-half years to develop a wireless, fully implantable device that will control the body’s circadian clock, halving the time it takes to recover from disrupted sleep/wake cycles.  The project will be led by a Northwestern University team of researchers and includes McGowan Institute for Regenerative Medicine affiliated faculty members Douglas Weber, PhD, Professor of Mechanical Engineering and Neuroscience at Carnegie Mellon University (CMU), and Tzahi Cohen-Karni, PhD, Assistant Professor in the Department of Biomedical Engineering at CMU. Read More

Landmark Data Presented for ZFUZE Surgical Polymer

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | June 9, 2021

DiFusion Technologies, Inc. recently announced landmark data for the company’s ZFUZE Surgical Polymer and how it compares to traditional biomaterials like Titanium and Poly-Ether-Ether-Ketone (PEEK). The data and the importance of the immune system response in new technologies such as ZFUZE were debated by Stephen Badylak, DVM, MD, PhD, Deputy Director of the McGowan Institute for Regenerative Medicine, Professor in the Department of Surgery at the University of Pittsburgh, and Director of the Center for Pre-Clinical Tissue Engineering within the Institute, at the International Society for Advancement of Spine Surgery (ISASS) in late May 2021 in Miami.  Dr. Badylak is a member of the Scientific Advisory Board of DiFusion Technologies, Inc. Read More

Prosthetic Hook Mouse for People with Upper-Limb Amputations

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | May 26, 2021

In recent decades, computer mice have become just as ubiquitous as computers. Now, thanks to Human Engineering Research Laboratories (HERL) and VA researchers, there’s even a prosthetic hook mouse for people with upper-limb amputations. Read More

DIY Device Climbs to the Top of the Charts

By The McGowan Institute For Regenerative Medicine | Awards and Recognition, Current News, Medical Devices | April 22, 2021

Michael Behrens, a student in the lab of McGowan Institute for Regenerative Medicine affiliated faculty member Warren Ruder, PhD, associate professor and William Kepler Whiteford Faculty Fellow of Bioengineering at Pitt, created a side project to optimize his lab work.  This side project piqued the interest of the global scientific community, putting it in the top 10 chemistry papers published in Scientific Reports in 2020. Read More

ALung Announces a Key Milestone Achievement in Its VENT-AVOID Pivotal Trial

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | March 25, 2021

ALung Technologies, Inc., the leading provider of low-flow extracorporeal carbon dioxide removal (ECCO2R) technologies for treating patients with acute respiratory failure, announced the recent achievement of a significant milestone – enrollment of 100 patients in its U.S. based VENT-AVOID pivotal trial. Read More

Pitt-McGowan Institute Center for Preclinical Studies Supports Total Artificial Heart Study

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | February 10, 2021
carmat tah

Carmat, a developer of an artificial heart which offers a bridge to transplant in patients with end-stage biventricular heart failure, recently reported its total artificial heart (TAH) received the European CE mark. The artificial heart provides an alternative for individuals for whom maximal medical therapy and left ventricular assist device are insufficient or contraindicated. It is designed for patients expected to receive a heart transplant within 180 days. Read More

Breathing Easier with a Better Tracheal Stent

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | January 21, 2021
drs c w k and t

Pediatric laryngotracheal stenosis (LTS), a narrowing of the airway in children, is a complex medical condition. While it can be something a child is born with or caused by injury, the condition can result in a life-threatening emergency if untreated.  Treatment, however, is challenging. Depending on the severity, doctors will use a combination of endoscopic techniques, surgical repair, tracheostomy, or deployment of stents to hold the airway open and enable breathing. Read More

Dr. Youngjae Chun Receives Second-Year Research Funding from The Children’s Heart Foundation

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | January 13, 2021
ychun

McGowan Institute for Regenerative Medicine affiliated faculty member Youngjae Chun, PhD, associate professor of industrial engineering and bioengineering at the University of Pittsburgh Swanson School of Engineering, will receive second-year research funding as part of more than $735,000 from The Children’s Heart Foundation, the nation’s leading organization dedicated to funding congenital heart defect (CHD) research. Read More

Synthetic Biology and Machine Learning Speed the Creation of Lab-Grown Livers

By The McGowan Institute For Regenerative Medicine | Computations and Modeling, Current News, Medical Devices | December 8, 2020
drs e and k

Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine-learning algorithm to create human liver organoids with blood- and bile-handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life. Read More

Podcast: What’s New in Military Medicine with Dr. Ron Poropatich

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | December 2, 2020
cmmr partnerships

At the University of Pittsburgh, the Center for Military Medicine Research (CMMR) recognizes the urgency for innovating to meet the demands of an increasingly complex security environment. Researchers have focused current and future efforts in the areas of trauma, emergency, and critical care. In doing so, the multi-disciplinary and multi-organizational-led team aims to significantly enhance the trauma care of the warfighter with direct relevance to civilian trauma care while also spurring the economic growth in the Pittsburgh region. Read More

Dr. Catalin Toma Reports Interim FLASH Registry Results on FlowTriever System

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | November 4, 2020
TomaC

The FlowTriever percutaneous mechanical thrombectomy system (Inari Medical) is safe and provides immediate benefits to patients with acute pulmonary embolism (PE), interim results of the real-world FLASH registry suggest.  McGowan Institute for Regenerative Medicine affiliated faculty member Catalin Toma, MD, Director of Interventional Cardiology for the Heart and Vascular Institute, Director of the Interventional Fellowship at UPMC, and an Assistant Professor of Medicine at the University of Pittsburgh School of Medicine, presented study results during TCT Connect 2020. Read More

Getting the Full Scope

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices, Neuroscience | October 28, 2020
3b kozai image

A neural interface — or brain-computer interface — is a device that uses electrical stimulation to induce changes in brain activity. Among other applications, its positive effects are being leveraged to rehabilitate neurological conditions, such as Parkinson’s disease. Read More

Monitoring Coronary Artery Disease in Real-Time

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | October 21, 2020
youngjae work

Coronary artery disease – a leading cause of death in the US – narrows or blocks arteries that carry a vital supply of blood, oxygen, and nutrients to the heart. A stent can be inserted to widen the artery, but these devices must be closely monitored to ensure that they do not re-narrow, a common complication called restenosis. Read More

Team Receives $1M NSF Award to Create At-Home Glaucoma Monitoring Device

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices, Vision | October 7, 2020
drs s and c

Diabetic patients monitor their blood glucose throughout the day, watching for peaks and valleys. Just taking a sample once during a visit to the doctor’s office would not give a clear picture of whether the patient’s diabetes is under control. The same is true of glaucoma patients, whose intraocular pressure (IOP), or pressure within the eye, is too high. Read More

HERL Receives Patent for Computer Pointing Device

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | October 7, 2020
cooper

University of Pittsburgh’s Human Engineering Research Laboratories (HERL) recently announced its latest patent to help improve mobility for people who use prosthetics. Read More

Tailor-Made Polymers Easier to Obtain

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | September 30, 2020
Matyjaszewski2

Polymer particles of any architecture, e.g. combs, stars, rings, have been produced for years thanks to the groundbreaking ATRP method discovered by Krzysztof Matyjaszewski, PhD, the J.C. Warner Professor of Natural Sciences at Carnegie Mellon University and affiliated faculty member of the McGowan Institute for Regenerative Medicine. Now scientists show how to carry out such reactions even more easily – in the presence of oxygen, in homelike conditions. Read More

Predictive Placentas: Using Artificial Intelligence to Protect Mothers’ Future Pregnancies

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | September 23, 2020
cmu placenta

After a baby is born, doctors sometimes examine the placenta—the organ that links the mother to the baby—for features that indicate health risks in any future pregnancies. Unfortunately, this is a time-consuming process that must be performed by a specialist, so most placentas go unexamined after the birth. A team of researchers from Carnegie Mellon University (CMU) and the University of Pittsburgh Medical Center (UPMC)—including McGowan Institute for Regenerative Medicine affiliated faculty member Philip Leduc, PhD, William J. Brown Professor of Mechanical Engineering with appointments in Biological Sciences, Computational Biology, and Biomedical Engineering at CMU—report the development of a machine learning approach to examine placenta slides in The American Journal of Pathology, published by Elsevier, so more women can be informed of their health risks. Read More

Blood-Thinner with No Bleeding Side-Effects Is On the Horizon

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | September 2, 2020
cook

Patients who suffer from thrombosis, pulmonary embolism or stroke are usually put on drugs that help their blood flow more smoothly through their body. Occupying a large section of the drug market, anticoagulants, or “blood thinners” as they are popularly known, can keep blood clots from forming or getting bigger, and can therefore help with recovery from heart defects or prevent further complications. Read More

SBIR Grant to Address Microvascular Obstructions

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | August 19, 2020
Pacella_2013

McGowan Institute for Regenerative Medicine affiliated faculty member John Pacella, MD, Associate Professor in the School of Medicine at the University of Pittsburgh and an Interventional Cardiologist within the UPMC Heart and Vascular Institute, is partnering with Microvascular Therapeutics (MVT), a biotechnology company based in Tucson, Arizona, and a leader in microbubble technology.  MVT recently was awarded a Phase I Small Business Innovation Research (SBIR) grant from the National Heart, Lung, and Blood Institute (NHLBI), a part of the National Institutes of Health. Read More

U.S. Department of Transportation Grants $1 Million to Pitt’s New University Transportation Center

By The McGowan Institute For Regenerative Medicine | Current News, Medical Devices | August 19, 2020
cooper

The U.S. Department of Transportation recently announced $4.925 million in grants to fund four new Tier 1 University Transportation Centers (UTCs) to advance research and education programs that address critical transportation challenges facing our nation.  The University of Pittsburgh was named one of the recipients of $1 million for its project entitled “Implications of Accessible Automated Vehicles and Mobility Services for People with Disabilities.” Read More

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