Hang Lin, PhD

Dr. Hang Lin is an Assistant Professor, Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, School of Medicine, University of Pittsburgh.

Dr. Lin received a BS in Biochemistry from the Nanjing University, Nanjing, P.R.China.  He received a PhD in Cell Biology from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, P.R.China.

Dr. Lin was a Visiting Fellow at the National Institute of Arthritis and Musculoskeletal and Skin, National Institutes of Health, Bethesda, MD.  He has been with the University of Pittsburgh since 2010, as a Postdoctoral Associate and a Research Assistaint professor.  He currently holds 4 patents. In 2017, he received the University of Pittsburgh Innovator Award.  He is also the NIA/NIH  Butler-Williams Scholar (2018).

Dr. Lin is a member of the Orthopaedic Research Society, the Biomedical Engineering Society, and the Tissue Engineering and Regenerative Medicine International Society. In addition to being an Editorial Board Member of the Frontiers in Bioengineering and Biotechnology – TE&RM, he is also a reviewer for several journals, including but not limited to, Science Advances, Biomaterials, Molecular Therapy, Tissue Engineering, and Stem Cell Research and Therapy.

Dr. Lin’s research interests focus on the study of articular joint diseases and the development of efficacious treatments.  For example, he had developed a method to apply visible light-based projection stereolithography (3D printing) on live cell fabrication. These 3D printed constructs can be further activated through the inclusion of vectors carrying therapeutic factors (gene-activated matrix/scaffold).  Working with collaborators from different institutions, he had developed micro-physiological joint organ chip (microJoint) in vitro, which offer novel capabilities for investigating the physiology of articular joint and the pathogenic mechanisms of osteoarthritis (OA), and serving as a high-throughput platform to test potential drugs for OA treatment. Currently, his lab is divided into 3 branches, which are interconnected but target different scientific questions:

  1. Tissue engineering and stem cell biology, including the mechanistic study of stem cell responses to substrate rigidity under 3D environment.
  2. Tissue chip modeling of synovial joint pathologies.
  3. Effect of chondrocyte aging on their regeneration potential and OA pathology

View a list of Dr. Lin’s publications here.

View Dr. Lin’s lab here.