Welcome to SPARK!

SPARK (Simple Platform for Agent-based Representation of Knowledge) is a cross-platform, free software for multi-scale agent-based modeling (ABM). Specifically, it provides some unique features for biomedical model development at the systems level. Our goal is to provide a lightweight, convenient, extensible and computationally efficient platform for ABM modelers. SPARK is under continuous development by the team at CIRM at the University of Pittsburgh.

Users Group

Figure: Cytokine level being monitored in a sample of liver tissue infected by Hepatitis C. blue dots – virus; green – HMGB1; red dots – portal triads.

Publications

Solovyev A; Mikheev M; Zhou L; Dutta-Moscato J; Ziraldo C; An G; Vodovotz Y. and Mi, Q., SPARK: A Framework for Multi-Scale Agent-based Biomedical Modeling, International Journal of Agent Technologies and Systems, 2010, 2(3):18-30.

Dutta-Moscato J; Solovyev A; Mi Q; Nishikawa T; Soto-Gutierrez A; Fox I; Vodovotz Y. A multiscale agent-based model of liver fibrosis progression. Frontiers Bioeng. Biotechnol. 2014. 2: Article 18.

Ziraldo C; Solovyev A; Allegretti A; Krishnan S; Henzel MK; Sowa GA; Brienza D; An G; Mi Q; Vodovotz Y. A Computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury. PLoS Comp. Biol. 2015. 11:e1004309.

Development Team

Project Leader: Qi Mi
Author: Alexey Solovyev
Developers: Alexy Solovyey, Maxim Mikheev, Qi Mi
Project Members: Leming Zhou, Joyeeta Dutta-Moscato, Cordelia Ziraldo, Gary An
CIRM Director: Prof. Yoram Vodovotz