Author: Arun Sharma; Rachel A. Clemens; Orquidea Garcia; D. Lansing Taylor; Nicole L. Wagner; Kelly A. Shepard; Anjali Gupta; Siobhan Malany; Alan J. Grodzinsky. Mary Kearns-Jonker, Devin B. Mair; Deok-Ho Kim; Michael S. Roberts; Jeanne F. Loring; Jianying Hu; Lara E. Warren; Sven Eenmaa; Joe Bozada; Eric Paljug; Mark Roth; Donald P. Taylor; Gary Rodrigue; Patrick Cantini; Amelia W. Smith; Marc A. Giulianotti; William R. Wagner

Title: Biomanufacturing in low Earth orbit for regenerative medicine

Summary: Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space.

Source: Stem Cell Reports: Perspective2022 Jan 11;17(1):1-13.  doi: 10.1016/j.stemcr.2021.12.001. Epub 2021 Dec 30.