Author: Arun Sharma; Rachel A. Clemens; Orquidea Garcia; D. Lansing Taylor; Nicole L. Wagner; Kelly A. Shepard; Anjali Gupta; Siobhan Malany; Alan J. Grodzinsky. Mary Kearns-Jonker, Devin B. Mair; Deok-Ho Kim; Michael S. Roberts; Jeanne F. Loring; Jianying Hu; Lara E. Warren; Sven Eenmaa; Joe Bozada; Eric Paljug; Mark Roth; Donald P. Taylor; Gary Rodrigue; Patrick Cantini; Amelia W. Smith; Marc A. Giulianotti; William R. Wagner Title: Biomanufacturing in low Earth orbit for regenerative medicine Summary: Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging [...]

Author: Luca Molinari; Gaspar Del Rio-Pertuz; Ali Smith; Douglas P. Landsittel; Kai Singbartl; Paul M. Palevsky; Lakhmir S. Chawla; David T. Huang; Donald M. Yealy; Derek C. Angus; John A. Kellum; for the ProCESS and ProGReSS-AKI Investigators Title: Utility of Biomarkers for Sepsis-Associated Acute Kidney Injury Staging Summary: Importance: The 23rd Acute Disease Quality Initiative (ADQI-23) consensus conference proposed a framework to integrate biomarkers into the staging of acute kidney injury (AKI). It is unknown whether tissue inhibitor of metalloproteinases 2 (TIMP-2) and insulinlike growth factor binding protein 7 (IGFBP7) could be used for staging. Objective: To test whether higher levels [...]

Author: Zheqi Li, Yang Wu, Megan E Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M Levine, Nolan M Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer Arnesen, Jason Gertz, Jennifer K Richer, Benjamin Troness, Dorraya El-Ashry, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Massimo Cristofanilli, Maritza A Montanez, Prithu Sundd, Callen T Wallace, Simon C Watkins, Caterina Fumagalli, Elena Guerini-Rocco, Li Zhu, George C Tseng, Nikhil Wagle, Jason S Carroll, Paul Jank, Carsten Denkert, Maria M Karsten, Jens-Uwe Blohmer, Ben H Park, Peter C Lucas, Jennifer M Atkinson, Adrian V Lee, Steffi Oesterreich Title: Hotspot ESR1 Mutations Are Multimodal and [...]

Author: Xinxiu Xu, Kang Jin, Abha S. Bai, Wenjuan Zhu, Hisato Yagi, Timothy N. Feinstein, Phong K. Nguyen, Joseph D. Criscione, Xiaoqin Liu, Gisela Beutner, Kalyani B. Karunakaran, Krithika S. Rao, Haoting He, Phillip Adams, Catherine K. Kuo, Dennis Kostka, Gloria S. Pryhuber, Sruti Shiva, Madhavi K. Ganapathiraju, George A. Porter Jr., Jiuann-Huey Ivy Lin, Bruce Aronow, Cecilia W. Lo Title: Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease Summary: Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease with 30% mortality from heart failure (HF) in the first year of [...]

Author: Michel Modo, Harmanvir Ghuman, Reem Azar, Ryan Krafty, Stephen F Badylak, T Kevin Hitchens Title: Mapping the acute time course of immune cell infiltration into an ECM hydrogel in a rat model of stroke using 19 F MRI Summary: Extracellular matrix (ECM) hydrogel implantation into a stroke-induced tissue cavity invokes a robust cellular immune response. However, the spatio-temporal dynamics of immune cell infiltration into peri-infarct brain tissues versus the ECM-bioscaffold remain poorly understood. We here tagged peripheral immune cells using perfluorocarbon (PFC) nanoemulsions that afford their visualization by 19F magnetic resonance imaging (MRI). Prior to ECM hydrogel implantation, only blood [...]

Author: Bing Han, Maria Giovanna Francipane, Amin Cheikhi, Joycelyn Johnson, Fei Chen, Ruoyu Chen, Eric Lagasse Title: Fat-associated lymphoid clusters as expandable niches for ectopic liver development Summary: Background and Aims: Hepatocyte transplantation holds great promise as an alternative approach to whole-organ transplantation. Intraportal and intrasplenic cell infusions are primary hepatocyte transplantation delivery routes for this procedure. However, patients with severe liver diseases often have disrupted liver and spleen architectures, which introduce risks in the engraftment process. We previously demonstrated i.p. injection of hepatocytes as an alternative route of delivery that could benefit this subpopulation of patients, particularly if less invasive [...]

Author: Junru Wu, Yoram Vodovotz, Sultan Abdelhamid, Francis X Guyette, Michael B Yaffe, Danielle S Gruen, Anthony Cyr, David O Okonkwo, Upendra K Kar, Neha Krishnamoorthi, Robert G Voinchet, Isabel M Billiar, Mark H Yazer, Rami A Namas, Brian J Daley, Richard S Miller, Brian G Harbrecht, Jeffrey A Claridge, Herbert A Phelan, Brian S Zuckerbraun, Pär I Johansson, Jakob Stensballe, James H Morrissey, Russell P Tracy, Stephen R Wisniewski, Matthew D Neal , Jason L Sperry, Timothy R Billiar, PAMPer study group Title: Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses Summary: Trauma is a [...]

Author: Amrita Sahu, Zachary J. Clemens, Sunita N. Shinde, Sruthi Sivakumar, Abish Pius, Ankit Bhatia, Silvia Picciolini, Cristiano Carlomagno, Alice Gualerzi, Marzia Bedoni, Bennett Van Houten, Mita Lovalekar, Nicholas F. Fitz, Iliya Lefterov, Aaron Barchowsky, Radosveta Koldamova & Fabrisia Ambrosio Title: Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles Summary: Heterochronic blood exchange (HBE) has demonstrated that circulating factors restore youthful features to aged tissues. However, the systemic mediators of those rejuvenating effects remain poorly defined. We show here that the beneficial effect of young blood on aged muscle regeneration was diminished when serum was depleted of extracellular [...]