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Grant of the Month | September 2012

    Grant of the Month Grant of the Month | September 2012

    Grant of the Month | September 2012

    By: The McGowan Institute For Regenerative Medicine | Category: Grant of the Month, Grant of the Month 2012 | September 1, 2012

    PI Naftali Kaminski

    Co-PI Michael John Becich and Stephen R Wisniewski

    Title Sarcoidosis and A1AT Genomics & Informatics Center

    Description Alpha-1 antitrypsin deficiency (A1 AT), an autosomal recessive genetic disease that is associated with a variable risk of COPD, and Sarcoidosis, a systemic disease characterized by the formation of granulomatous lesions especially In the lungs, liver, skin, and lymph nodes that leads to a dramatically heterogeneous set of clinical manifestations, differ in etiology and clinicl presentation but share a variable and unpredictable course. To improve disease classification, facilitate biomarker discovery and accelerate advent of novel therapy an integrative approach that combines the results of clinical studies with molecular phenotyping results is required. The Sarcoidosis and A1 AT Genomics and Informatics Center (SAGIC) will facilitate this process by addressing the following objectives for the NHLBI Genomic Research In A1 AT and Sarcoidosis (GRADS) program: 1) Coordination of Clinical Centers activities that include patient recruitment and phenotyping and biospecimen collection. 2) Performance of transcriptome and microbiome analyses of the samples obtained by the Clinical Centers, 3) Data analysis and integration, 4) Dataset preparation for deposit in the NHLBI BloLINCC repository. The objectives will be addressed through two research projects. Project 1: A1 AT microbiome – will address the hypothesis that shifts in the lung microbiome determine the extent of lung involvement In A1 AT and that they are reflected in mRNA and microRNA changes in surrogate tissues, and Project 2: Novel molecular phenotypes in Sarcoidosis – will address the hypothesis that systemic Inflammation as reflected in gene expression changes in PBMC Is indicative of disease extent, microbiome shifts and granuloma molecular networks.

    Source NHLBI

    Term 05/01/12 – 04/30/15

    Amount $2,068,387

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    • Home
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      • Partnerships & Collaborations
        • Industry
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    • About Us
      • Welcome
      • Video
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      • Mission Statement
      • What Is Regenerative Medicine?
      • Contact Us
      • Clinical Site
    • Our Research
      • Focus Areas
        • Tissue Engineering and Biomaterials
        • Cellular Therapies
        • Medical Devices and Artificial Organs
        • Clinical Translation
      • Matrix
      • Centers
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      • Clinical Trials
      • Initiatives
    • Media
      • Current News
      • News Archive
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      • Newsletter
      • Grant of the Month
      • Publication of the Month
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      • Special Events
      • Student Interest Groups
      • CATER
      • Post-Doctoral Opportunities
      • Career Opportunities
      • Wiegand Summer Internship
      • Admissions
      • Summer School
      • 2019 Scientific Retreat
      • Human Performance Optimization Symposium
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