PI Harvey S. Borovetz, PhD
Title Pediatric Circulatory Support
Summary The PediaFlow™ is a miniature magnetically levitated turbodynamic VAD for pediatric patients ranging from birth weight to 15 kg. Our design is based on extensive computational modeling. CFD analysis was used to optimize the flow field for efficiency and hemocompatibility and reach a design point of 0.5 L/min at a 110 mm Hg pressure head.
The current (1st generation) PediaFlow™ design is 51 mm in length with a diameter of 28 mm. Its total mass is approximately 100 g. Prototypes are currently undergoing in vitro performance tests and flow path visualization and quantification. In vivo evaluation is planned during the current grant year.
New platelet activation detection assays are being developed in Dr. Wagner’s lab to assess hemocompatibility of the device both in vivo and ex vivo. A second generation prototype is planned by the end of calendar year 2007. This improved version will aim at decreased size, anatomic compatibility with typical congenital anomalies and excellent biocompatibility when implanted in perigestational lamb models which approximate the size of the intended pediatric patient.
Source NIH (HHSN268200448192C)
Term 02/15/04 – 03/29/09
