PI: Rocky S. Tuan
Co-I: Peter Alexander and Riccardo Gottardi
Title: A Microphysiological 3D Organotypic Culture System for Studying Degradation and Repair of Composite Skeletal Tissues in a Microgravity Environment
Description: In search of medicinal treatments for bone loss, a 3D MPS will be used to test potential therapies related to osteoporosis and other musculoskeletal disorders. This specific MPS model for bone avoids the complexities found in animal modeling, which can be confounded by species-specific responses. The project will study this MPS in microgravity, which induces bone loss, to confirm the protective role of bisphosphonates (a class of drugs currently used to treat osteoporosis) for protection during long-term microgravity exposure. Musculoskeletal diseases (including arthritis, back pain, fracture, osteoporosis, sports trauma, and other ailments) affect more than 50% of adults in the US and nearly 75% of those age 65 and over. If effective, this study hopes to reduce the cost and expedite the process of identifying potential therapeutic compounds for the treatment of musculoskeletal disorders.
Source: Center for the Advancement of Science in Space
Term: 4/30/16 – 12/31/17