• Pitt
  • Health Sciences
  • UPMC
Regenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan Institute
  • Home
  • Our People
    • Faculty/Staff Bios
    • Core Faculty Publications
    • Administrative Resources
  • Our Technologies
  • About Us
    • Welcome
    • Video
    • Statistics
    • Mission Statement
    • What Is Regenerative Medicine?
    • Executive Committee
    • Contact Us
    • Clinical Site
  • Our Research
    • Focus Areas
      • Tissue Engineering and Biomaterials
      • Cellular Therapies
      • Medical Devices and Artificial Organs
      • Clinical Translation
    • Matrix
    • Centers
    • Laboratories
    • Clinical Trials
    • Initiatives
  • Media
    • Current News
    • News Archive
    • Video
    • Podcasts
    • Newsletter
    • Grant of the Month
    • Publication of the Month
    • Media Contact
    • Video Links
  • Professional Development
    • Seminar Series
    • Special Events
    • Student Interest Groups
    • CATER
    • Post-Doctoral Opportunities
    • Career Opportunities
    • Wiegand Summer Internship
    • Admissions
    • Summer School
    • 2021 Scientific Retreat
    • Human Performance Optimization Conference

Development of a Mantle Cell Lymphoma Cell Culture Model

    Computations and Modeling Development of a Mantle Cell Lymphoma Cell Culture Model

    Development of a Mantle Cell Lymphoma Cell Culture Model

    By: The McGowan Institute For Regenerative Medicine | Category: Computations and Modeling, News Archive | September 4, 2019

    whitehead 2019

    Mantle cell lymphoma is an aggressive subtype of non-Hodgkin’s lymphoma that claims the lives of tens of thousands of people every year. Mantle cell lymphoma is considered incurable, even though new treatments have yielded promising results.

    The combination chemotherapy regimen CHOP has a high response rate in patients. However, the cancer becomes resistant to treatment over time, and the duration of the response is often less than three years.

    The development of effective treatments for patients with advanced disease is hampered by the lack of conventional cell culture and preclinical models of mantle cell lymphoma that recapitulate the chemoresistance seen in patients. The lack of chemoresistant models has also limited understanding of the mechanisms used by cells to acquire resistance.

    In a study recently published in Experimental Biology and Medicine, McGowan Institute for Regenerative Medicine affiliated faculty member Kathryn Whitehead, PhD, Associate Professor in the Departments of Chemical Engineering and Biomedical Engineering at Carnegie Mellon University, and colleagues describe the generation of a chemoresistant mantle cell lymphoma cell line that mimics the low-level resistance observed in patients.

    JeKO-1 cells treated with increasing concentrations of the chemotherapy cocktail CHOP developed tolerance to CHOP treatment and exhibited rapid proliferation when exposed to therapeutic levels of CHOP. These cells also exhibited increased expression of three oncogenes implicated in the development of mantle cell lymphoma–Cyclin D1, Mcl-1 and Bcl-1.

    Dr. Whitehead said, “A significant challenge in cancer therapy today is a lack of models that are representative of true human disease. We are pleased to have developed a mantle cell lymphoma cell culture model that recapitulates typical levels of chemoresistance in patients.”

    Read more…

    MENAFN

    Paper (Development of a clinically relevant chemoresistant mantle cell lymphoma cell culture model.  Jia He, Khalid A Hajj, Christopher M Knapp and Kathryn A Whitehead.  Experimental Biology and Medicine 2019; 244: 865–872.)

    Print Friendly
    No tags.

    • site map
    • links
    • contact
    • subscribe to our newsletter
    © Copyright 2021 McGowan Institute for Regenerative Medicine
    A program of the University of Pittsburgh and the University of Pittsburgh Medical Center
    • Home
    • Our People
      • Faculty/Staff Bios
      • Core Faculty Publications
      • Administrative Resources
    • Our Technologies
    • About Us
      • Welcome
      • Video
      • Statistics
      • Mission Statement
      • What Is Regenerative Medicine?
      • Executive Committee
      • Contact Us
      • Clinical Site
    • Our Research
      • Focus Areas
        • Tissue Engineering and Biomaterials
        • Cellular Therapies
        • Medical Devices and Artificial Organs
        • Clinical Translation
      • Matrix
      • Centers
      • Laboratories
      • Clinical Trials
      • Initiatives
    • Media
      • Current News
      • News Archive
      • Video
      • Podcasts
      • Newsletter
      • Grant of the Month
      • Publication of the Month
      • Media Contact
      • Video Links
    • Professional Development
      • Seminar Series
      • Special Events
      • Student Interest Groups
      • CATER
      • Post-Doctoral Opportunities
      • Career Opportunities
      • Wiegand Summer Internship
      • Admissions
      • Summer School
      • 2021 Scientific Retreat
      • Human Performance Optimization Conference
    Regenerative Medicine at the McGowan Institute