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Grant of the Month

Media Grant of the Month
(Page 4)

Grant of the Month | November 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | November 1, 2009
PI Eric Lagasse

Title Organogenesis of Ectopic Tissue in Lymph Node

Description Our proposal addresses some of the solutions to the development of complex 3-dimensional tissue models and a new paradigm by using lymph node as in vivo bioreactors to grow tissue or organ substitute. Our initial study and prove of concept will be centered around the generation of ectopic liver in lymph nodes for patients suffering end-stage liver diseases. Hepatocyte transplantation has been reported as a possible therapeutic approach for liver disease. However, transplantation has been directed at the liver itself, limiting efficacy in patients with end-stage liver diseases, when cirrhosis and fibrosis are common. In this proposal we demonstrate that the generation of an ectopic liver within lymph nodes is an efficient method to restore hepatic function, highlighting the novel use of this organ as a site for hepatocyte transplantation. Homeostatic expansion of donor hepatocytes in lymph nodes resulted in the rescue of lethal hepatic failure. These data provide the first definitive evidence that a functional ectopic liver can rescue lethal hepatic diseases. Furthermore, with the efficacy of this approach suggests that lymph nodes have therapeutic potential for cell-based transplantation and tissue engineering. Our new paradigm to generate functional liver tissues in lymph nodes will be further applied to other tissues.

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Grant of the Month | October 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | October 1, 2009
PI J. Peter Rubin

Title Biomedical Translational Initiative: Structural Fat Grafting for Craniofacial Trauma

Description Facial trauma injuries, especially those sustained in military combat, are characterized by destruction of bone and soft tissue anatomy. While the bony skeleton can often be reconstructed, the overlying soft tissue is difficult to restore. Importantly, it is the structure of the soft tissue that imparts the normal human form, and adequate reconstruction of soft tissue defects allows trauma victims to reintegrate into society. Current procedures for soft tissue reconstruction of the face primarily involve tissue flap reconstruction procedures. Synthetic (e.g silicone) implants for soft tissue trauma of the face have no practical role and are fraught with complications and poor results. Tissue flap operations are extensive, often including microvascular surgery, and do not precisely correct the deformities. Autologous fat grafting, performed through a minimally invasive means, has the potential to correct deformities with much greater precision and lower morbidity.

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Grant of the Month | September 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | September 1, 2009
PI Joseph Ahearn

Co-Investigator William Wagner

Title Molecular and Functional Characterization of the Lupus Platelet

Description The platelet plays critical roles in control of abnormal bleeding, in formation of pathologic thromboses, and in molecular and cellular mechanisms of inflammation, wound healing, and the immune response. Recently it has been found that platelets can also participate in atherothrombosis and inflammation through the formation and release of membrane-bound vesicles called microparticles. These platelet-derived microparticles (PMP) readily circulate in the vasculature and exhibit procoagulant activity. Platelets and PMP are likely to contribute to myriad manifestations of lupus, although they appear to be relatively understudied in this regard. We have recently discovered that platelets bearing complement activation product C4d (PC4d) are highly specific for lupus versus other inflammatory diseases (98%) and versus healthy subjects (100%). PC4d-positivity in patients with lupus is associated with neuropsychiatric and thrombotic manifestations of the disease. Through imaging and flow cytometric studies we have since discovered that PC4d associates not only with intact platelets, but also with membrane-bound PMP. This study has two central hypotheses: first, that C4d deposition on platelets and PMP has functional consequences that contribute to thrombotic manifestations in lupus, and second, that platelets bearing C4d hold molecular clues to a pathway responsible for the PC4d phenotype and to pathways that lead to the functional consequences of PC4d deposition. This application will specifically focus on determining differences, both functional and molecular, between PC4d-positive and PC4d-negative platelets in patients with SLE. This will be accomplished through three specific aims. The first aim is to investigate functional differences between PC4d-positive and PC4d-negative platelets with regard to thrombogenesis and atherogenesis. The second aim is to investigate the functional effect of PC4d-positive versus PC4d-negative PMP on immune cells and other cellular components of the vasculature. The third aim is to identify specific protein differences in C4d-positive platelets compared to C4d-negative platelets in patients with SLE and in healthy controls. Successful completion of the proposed studies should advance our understanding of the functional role of platelets, PMP, and complement in the thrombotic manifestations of lupus. In addition, identification of a lupus platelet proteomic signature would elucidate important molecular and cellular mechanisms of thrombotic and other complications of lupus and would identify potential therapeutic targets.

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Grant of the Month | August 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | August 1, 2009
PI W. P. Andrew Lee MD

Co-Investigators Jörg Gerlach,MD, PhD and Jack Patzer, PhD

Title Long-term immunosuppression-free survival of a combined composite tissue allograft (CTA) and autologous skin in a swine model

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Grant of the Month | July 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | July 1, 2009
PI Stephen Badylak and Michael Sacks

Co-Investigators Thomas Gilbert

Title Mechanobiology and Regenerative Medicine

Description Regenerative medicine approaches for the reconstitution of missing or injured tissues and organs involves the use of scaffolds, cells, and bioactive molecules. The use of biologic scaffolds seeded with cells is a common approach and several applications have been successfully translated to clinical medicine including lower urinary tract, gastrointestinal tract, musculotendinous, and dermal skin regeneration. The principles that guide tissue remodeling and regeneration are only partially understood but the influence of biomechanical loading upon the remodeling process is accepted as an important variable. However, there is an almost complete absence of systematic, quantitative studies to determine the effect of this controllable factor upon tissue remodeling, especially tissues with a smooth muscle wall component.

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Grant of the Month | June 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | June 1, 2009
PI Steven Little, PhD

Title Temporal Delivery of Growth Factors for Wound Healing Using Porous Hollow Fibers

Description Our objective is to optimize wound healing through temporal delivery of growth factors using porous hollow fibers extending into a wound site. As an extension to the wound-cap technology (artificial capillary bed delivery system), these fibers can be made from materials that dissolve in the presence of a chemical or temperature-based trigger following the wound healing process. Because angiogenesis is, in many cases, one of the first steps towards wound healing, we propose to demonstrate enablement of this technology by mimicking the natural sequence of stimuli that directs angiogenesis. Our hypothesis is that sequential delivery of appropriate angiogenesis-promoting factors from our externally-regulated delivery system, as opposed to simultaneous delivery of multiple factors, will result in more mature and integrated neo-vasculature.

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Grant of the Month | May 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | May 1, 2009
PI Thomas Gilbert, PhD

Co-Investigators Kimimasa Tobita, MD, PhD and Stephen Badylak, DVM, MD, PhD

Title Cardiac Remodeling with Organ Specific Extracellular Matrix Scaffolds

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Grant of the Month | April 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | April 1, 2009
PI Johnny Huard

Title Tissue Engineered Skeletal Muscle (TESM) from Muscle Progenitor Cells: A Model for Studying Insulin Resistance and Muscle Metabolism

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Grant of the Month | March 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | March 1, 2009
PIs: Steven Belle and Kyong-Mi Chang

Co. Investigator: Robert Carithers, Adrian Di Bisceglie, Michael Fried, Marc Ghany, Steven Han, E. Jenny Heathcote, W. Ray Kim, Daryl Lau, William Lee, Anna Lok, Mitchell Shiffman, KathleenSchwarz, and Norah Terrault

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Grant of the Month | February 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | February 1, 2009
PI: Steven F. Badylak, DVM, PhD, MD

Title: Regenerative Medicine Approach to the Treatment of Abdominal Compartment Syndrome in a Dog Model

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Grant of the Month | January 2009

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2009 | January 1, 2009
PIs: Rick Koepsel

Co. Investigator: Sharon Marx and Gabriel Amitai

Title: Temperature responsive modification of microfiber tissue perfusion devices.

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Grant of the Month | December 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | December 1, 2008
PIs: Alan Russell

Co-PIs: Marina Kameneva, William Wagner, Jörg Gerlach, Mark Yazer

Title: Large Scale Human Placenta Progenitor Cell-Derived Erythrocyte Production – Continuous Red Blood Cell Production

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Grant of the Month | November 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | November 1, 2008
PIs: Edward V. Prochownik

Co-PIs: Eric Lagasse, William Saunders, and Youjun Li

Title: Function of a Glycoprotein Ibα, a Subunit of the Von Willebrand’s Factor Receptor as a Transforming Oncoprotein

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Grant of the Month | October 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | October 1, 2008
PIs: William Federspiel, PhD

Co-PIs: Alan Russell, PhD and William Wagner, PhD

Title: Percutaneous Respiratory Assist Catheter

Description: Each year several hundred thousand Americans suffer short term lung failure requiring respiratory support within the intensive care unit. The objective of this proposal is to develop a percutaneous respiratory assist catheter (PRAC) that can be inserted into the venous system to provide supplemental breathing support, independent of the lungs, for patients requiring short-term (~ 4-7 day) respiratory assistance.

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Grant of the Month | September 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | September 1, 2008
PIs: Yoram Vodovotz, PhD

Co-PIs: Gregory M. Constantine, PhD (Pitt—Mathematics); Steve Chang (CEO of Immunetrics); Drs. Gary Nieman and Kris Maier (SUNY-Syracuse)

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Grant of the Month | August 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | August 1, 2008
PIs: Bradley Keller, MD

Co-PIs: William Wagner, PhD

Title: Engineered Early Embryonic Cardiac Tissue

Description: We have developed an Engineered Early Embryonic Cardiac Tissue, termed EEECT, using embryonic cardiac cells isolated during the period of primary morphogenesis in order to investigate the regulation of embryonic CM proliferation and differentiation and to generate tissues with optimal properties for cardiac repair. Our EEECT construct uses a simple cylindrical geometry which is reproducible, scalable, and preserves the unique proliferative and contractile properties of developing myocardium. Using EEECT we can investigate the regulation of CM proliferation and maturation within a functioning in vitro 3D environment. EEECT proliferation and force production increases in response to cyclic mechanical stretch. With prolonged culture EEECT acquires a post-natal myocardial phenotype (reduced proliferation, increased calcium and β-adrenergic sensitivity, and increased force production). Preliminary data show that cylindrical EEECT can be implanted onto recipient injured adult myocardium as part of a cardiac repair/recovery strategy. Implanted EEECT survive, proliferate, and functionally contribute to recipient cardiac functional recovery.

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Grant of the Month | July 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | July 1, 2008
PI G. Bard Ermentrout, PhD, Beatrice Riviere, PhD, Jonathan Rubin, PhD, David Swigon, PhD, and Ivan Yotov, PhD

Title Research Training Group Award

Summary Will provide resources to develop training programs for mathematics students to work with physicians and biologists to help resolve complicated medical problems through mathematics. A variety of computer models will be produced based on differential equations to create immune system models to plot the various chemical and physical changes that occur as the body battles influenza, inflammation, sepsis, necrosis, and wounds. The researchers hope to be able to plot and pinpoint the origin of uncontrollable inflammation and infection that can occur as complications following surgery.
Source

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Grant of the Month | June 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | June 1, 2008
PI Stephen Badylak, DVM, PhD, MD

Title Four Projects Funded by CR Bard, Inc.

Summary In vivo and in vitro evaluation of porcine dermal product for pelvic floor and body wall (hernia) reconstruction. ($90,000)
Manufacturing process review and modification. ($96,000)
In vitro characterization of porcine dermis ECM and products in development. ($118,000)
Evaluation of gel form of porcine dermal matrix. ($60,130)

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Grant of the Month | May 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | May 1, 2008
PI Edward Prochownik, MD, PhD and Eric Lagasse, PharmD, PhD

Title Function of a Glycoprotein lba, a Subunit of the von Willebrand’s Factor Receptor as a Transforming Oncoprotein

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Grant of the Month | March 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | March 1, 2008
PI Eric Lagasse, PhD

Co-PI(s) Joerg Gerlach

Title Ovarian Cancer, Stem Cells and Bioreactors

Summary Addressing the needs of new approaches for anti-cancer therapies by combining stem cell biology, cancer biology and bioengineering. Our central hypothesis is that cancer stem cells are initiating and sustaining the growth of ovarian cancer. In consequence, the identification of the cancer stem cells represents a major step forward in the elucidation of ovarian cancer hierarchy and could hold the key to understanding the origin and maintenance of ovarian cancer, the relapses and possibly the metastases in advanced cases. Another problem facing cancer cell biology is the access of in vitro culture models for research and study of cancer development and its pathophysiology. Here we propose to adopt bioreactors used for bioartificial livers (BAL) to provide tumor cells with a 3-D perfusion culture instrument that recapitulate vasculature and microenvironment.

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Grant of the Month | April 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | March 1, 2008
PI Alan J. Russell, PhD and Anthony Atala, MD

Title Armed Forces Institute for Regenerative Medicine

Summary The University of Pittsburgh’s McGowan Institute for Regenerative Medicine and the Institute for Regenerative Medicine at Wake Forest University Baptist Medical Center have been selected as co-leaders of a national $85 million program to use the science of regenerative medicine to develop new treatments for wounded soldiers.

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Grant of the Month | February 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | February 1, 2008
PI Stephen Badylak and Joerg Gerlach

Title Advanced Regenerative Medicine (ARM) Therapies for Combat Injuries

Summary Badylak: Digit regeneration using porcine derived scaffolds
Gerlach: Wound cap for tissue regeneration
Gerlach: Skin gun for burn therapy

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Grant of the Month | January 2008

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2008 | January 1, 2008
PI Harvey Borovetz, PhD

Title Levitronix Phase II SBIR

Summary Development of a magnetically levitated, bearingless pump for a pediatric ventricular assist device.

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Grant of the Month | December 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | December 1, 2007
PIs: William Wagner, PhD

Title: Cardiopulmonary Organ Engineering

Description: Researchers are currently working to develop tissue constructs that could be utilized to repair congenital heart defects and to recover function lost to myocardial infarction. The general approach involves optimizing the combination of precursor cells with synthetic scaffolds and culturing methods to achieve the functionality required for the given application. The research team working on this project includes cardiothoracic surgeons, bioengineers, polymer chemists, cell biologists and electrophysiologists.

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Grant of the Month | November 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | November 1, 2007
PIs: Satdarshan P. Singh Monga, MD

Title: Beta-catenin in the growth of hepatocellular cancer

Description: Hepatocellular cancer (HCC) is a disease of poor prognosis. Identifying novel molecular aberrations might present opportunities to identify new therapeutic targets. Due to the similarities between the processes of development and cancer, we used early developing livers to identify genes that might play a primary role in HCC. Platelet-derived growth factor receptor-alpha (PDGFRalpha) was identified from microarray using early developing mouse livers. Expression of PDGFRalpha and its upstream effectors, PDGF-AA and PDGF-CC, were examined in HCC tissues (n = 43) by Western blot, real-time PCR, and immunohistochemistry. Finally, effect of anti-PDGFRalpha antibody (mAb 3G3, ImClone Systems, Inc.) was examined on human hepatoma cells. A high expression of PDGFRalpha was observed during early liver development. HCCs (17 of 21) revealed cytoplasmic PDGFRalpha and activated PDGFRalpha (phospho-Tyr(754)) by immunohistochemistry. Additional HCCs (14 of 22) showed elevated PDGFRalpha levels when compared with the adjacent normal livers by Western blots. Of these 14 patients, 3 showed increased PDGFRalpha gene expression, 3 showed elevated PDGF-AA, and 4 had higher PDGF-CC levels in the tumors compared with adjacent livers. Multiple hepatoma cell lines, when treated with mAb 3G3, showed significant decreases in cell proliferation and survival (P < 0.05). In conclusion, approximately 70% of HCC tissues had elevated PDGFRalpha levels due to diverse mechanisms. PDGFRalpha inhibition in hepatoma cells led to diminution of tumor cell survival and proliferation and thus might be of therapeutic significance.

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Grant of the Month | October 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | October 1, 2007
PIs: Michael S. Sacks, Ph.D.

Co-PIs: Dr. Joyce Bischoff, Dr. David Brown, Dr. Danielle Gottlieb, Dr. John Mayer, Dr. Robert Padera, Dr. Andrew Powell, Dr. Virna Sales, Dr. Frederick Schoen, Dr. George Stetten

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Grant of the Month | September 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | September 1, 2007
PIs: Jean Latimer

Co-PIs: Stephen Grant and Michael Epperly

Title: Biomarkers of invasiveness using isogenic and progressive human ductal carcinoma in situ cell lines

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Grant of the Month | August 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | August 1, 2007
PIs: Kacey G. Marra, PhD

Co-PIs: Douglas Weber, PhD

Title: Surface Modified Polymer Conduits for Peripheral Nerve Repair

Description: The project seeks to increase the understanding of the effects of biomaterial surface properties on nerve regeneration, and also to enhance the integrated research and education activities of graduate, undergraduate and pre-college students. The plan includes outreach programs and innovative research in the exciting areas of biomaterials and tissue engineering. Specifically, the research plan is focused on developing biodegradable conduits with modified inner luminal surfaces that enhance peripheral nerve repair over long gaps, and the educational plan is focused on enhancing and maintaining the involvement of women and underrepresented minorities in engineering.

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Grant of the Month | July 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | July 1, 2007
PI Stephen Badylak, DVM, PhD, MD

Co-PI(s) Susan Braunhut, Ph.D., professor of biological sciences at the University of Massachusetts at Lowell
Lorraine Gudas, Ph.D., chairman of the pharmacology department and Revlon Pharmaceutical Professor of Pharmacology and Toxicology, Weill Medical College of Cornell University, New York City
Ellen Heber-Katz, Ph.D., professor, molecular and cellular oncogenesis program, The Wistar Institute in Philadelphia
Shannon Odelberg, Ph.D., assistant professor, departments of internal medicine and neurobiology and anatomy, University of Utah, Salt Lake City
Hans-Georg Simon, Ph.D., a developmental biologist and assistant professor of pediatrics, Children’s Memorial Research Center and Northwestern University in Chicago

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Grant of the Month | June 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | June 1, 2007
PI Billy W. Day, PhD and Jean J. Latimer, PhD

Title “Quantitative proteomics of nuclear matrix proteins in novel human ductal carcinoma in situ model systems”
Summary Background: Ductal carcinoma in situ (DCIS) is the earliest identifiable breast cancer lesion. Because DCIS is a pre-invasive malignancy, a better understanding of if and how it may progress to invasive disease will allow determination of which patients to treat aggressively and avoid unnecessary aggressive procedures. Once determined, these differentially expressed proteins may be used as biomarkers or therapeutic targets, as well as help determine the paths by which normal cells progress to DCIS plus provide a better understanding of breast carcinogenesis and ways to prevent it. Tumor grade, size and presence of necrosis are currently used to make clinical decisions regarding DCIS.

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Grant of the Month |May 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | May 1, 2007
PI Stephen F. Badylak, DVM, MD, PhD

Title Biomechanical Soldier Treatment and Regeneration Consortium (STRaC): Preclinical Study to evaluate the use of UBM-ECM for Partial Thickness Skin Wounds

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Grant of the Month |April 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | April 1, 2007
PI Michael Sacks, PhD

Co-PI(s) William Wagner, PhD

Title Biomechanical Optimization of Tissue Engineered Heart Valves
Summary The focus of this competitive renewal grant is a comprehensive biomechanical evaluation of the in-vitro phase of engineered tissue heart valve development.

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Grant of the Month |March 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | March 1, 2007
PI Derek C. Angus, M.D., M.P.H

Co-PI(s) Donald M. Yealy, M.D and Mitchell P. Fink, M.D.

Title Protocolized Care for Early Septic Shock (ProCESS)

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Grant of the Month |February 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | February 1, 2007
PI See below

Title National Tissue Engineering Center (Multiple Awards)

Summary Regenerative Medicine Approach to the Treatment of Abdominal Compartment Syndrome in a Dog Model

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Grant of the Month | January 2007

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2007 | January 1, 2007
PI John A. Kellum, MD

Title Biological Markers of Recovery for the Kidney (BioMaRK)

Summary Investigate the role of inflammation, as well as other factors in recovery from acute renal failure (ARF). This project, called Biological Markers of Recovery for the Kidney, or BioMaRK, will examine how such factors influence survival as well as recovery of kidney function. The study will assess how certain inflammation markers relate to clinical outcomes and build a risk-prediction model based on clinical variables and those biomarkers. The results of this study could potentially lay the foundation for the development of ARF treatment therapies, particularly those designed to enhance organ recovery.

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Grant of the Month | December 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month | December 1, 2006
PI David Vorp, PhD

Co-PI(s) Michael Chancellor, MD; Douglas Chew, BS; Johnny Huard, PhD; Naoki Yoshimura, MD, PhD

Title Bioengineered Urethral Augmentation

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Grant of the Month | November 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | November 1, 2006
PI David Vorp, PhD

Co-PIs Michael Chancellor, MD; Douglas Chew, BS; Johnny Huard, PhD; Naoki Yoshimura, MD, PhD

Title Bioengineered Urethral Augmentation

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Grant of the Month | October 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | October 1, 2006
PI J. Peter Rubin, M.D.

Co-PIs Kacey G. Marra, Ph.D., Albert D. Donnenberg, Ph.D., Vera S. Donnenberg, Ph.D., Stephen Badylak, D.V.M., M.D., Ph.D., and Howard D. Edington, M.D.

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Grant of the Month | September 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month | September 1, 2006
PI Mitchell P. Fink, MD

Co-PI(s) Marina V. Kameneva, PhD and Alan J. Russell, PhD

Title Next Steps in the Development of Drag Reducing Polymers for Treatment of Life-Threatening Hemmorrhagic Shock in Combat Casualties Using Small Volumes of Resuscitation Fluid

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Grant of the Month | August 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | August 1, 2006
PI Eric Lagasse

Title Metastatic Colon Cancer, Stem Cells, and Artificial Bioreactors

Summary This study will focus on the cellular characterization of metastatic colon cancer in the liver and a 3-D perfusion culture instrument that recapitulates hepatic vasculature and microenvironment. Colon cancer is a very common cancer second only to lung cancer. Distant metastases are one of the worst prognostic signs as this places the patient in the most advanced staging category. Colon cancers generally spread through the lymphatics or through the portal venous system to the liver. The liver is the most frequent visceral site of metastatic dissemination and is the initial site of distant spread in one-third of recurring colon cancers, with two-thirds of patients having liver involvement at the time of death. The median survival after the detection of distant metastases range from 6 to 9 months (with heavy liver involvement) to 24 to 30 months (with initially small liver nodules).

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