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Yearly Archives: 2006

2006

Grant of the Month | December 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month | December 1, 2006
PI David Vorp, PhD

Co-PI(s) Michael Chancellor, MD; Douglas Chew, BS; Johnny Huard, PhD; Naoki Yoshimura, MD, PhD

Title Bioengineered Urethral Augmentation

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Grant of the Month | November 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | November 1, 2006
PI David Vorp, PhD

Co-PIs Michael Chancellor, MD; Douglas Chew, BS; Johnny Huard, PhD; Naoki Yoshimura, MD, PhD

Title Bioengineered Urethral Augmentation

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Grant of the Month | October 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | October 1, 2006
PI J. Peter Rubin, M.D.

Co-PIs Kacey G. Marra, Ph.D., Albert D. Donnenberg, Ph.D., Vera S. Donnenberg, Ph.D., Stephen Badylak, D.V.M., M.D., Ph.D., and Howard D. Edington, M.D.

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Grant of the Month | September 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month | September 1, 2006
PI Mitchell P. Fink, MD

Co-PI(s) Marina V. Kameneva, PhD and Alan J. Russell, PhD

Title Next Steps in the Development of Drag Reducing Polymers for Treatment of Life-Threatening Hemmorrhagic Shock in Combat Casualties Using Small Volumes of Resuscitation Fluid

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Grant of the Month | August 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | August 1, 2006
PI Eric Lagasse

Title Metastatic Colon Cancer, Stem Cells, and Artificial Bioreactors

Summary This study will focus on the cellular characterization of metastatic colon cancer in the liver and a 3-D perfusion culture instrument that recapitulates hepatic vasculature and microenvironment. Colon cancer is a very common cancer second only to lung cancer. Distant metastases are one of the worst prognostic signs as this places the patient in the most advanced staging category. Colon cancers generally spread through the lymphatics or through the portal venous system to the liver. The liver is the most frequent visceral site of metastatic dissemination and is the initial site of distant spread in one-third of recurring colon cancers, with two-thirds of patients having liver involvement at the time of death. The median survival after the detection of distant metastases range from 6 to 9 months (with heavy liver involvement) to 24 to 30 months (with initially small liver nodules).

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Grant of the Month | July 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | July 1, 2006
PI William R. Wagner

Title Cardiopulmonary Organ Engineering

Summary The aim of this proposal is to design solutions for vascular, cardiac, and pulmonary organ failure by building interactive teams of researchers focused on specific aspects of cardiopulmonary organ engineering. Our efforts will address a tissue engineered blood vessel, and a myocardial patch. The assembled research teams will function as cores of expertise that address common tasks associated with each of the projects. Five research cores will be established in the following areas:

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Grant of the Month | May 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | May 1, 2006
PI Harvey S. Borovetz, PhD

Title Pediatric Circulatory Support

Summary The PediaFlow™ is a miniature magnetically levitated turbodynamic VAD for pediatric patients ranging from birth weight to 15 kg. Our design is based on extensive computational modeling. CFD analysis was used to optimize the flow field for efficiency and hemocompatibility and reach a design point of 0.5 L/min at a 110 mm Hg pressure head.
The current (1st generation) PediaFlow™ design is 51 mm in length with a diameter of 28 mm. Its total mass is approximately 100 g. Prototypes are currently undergoing in vitro performance tests and flow path visualization and quantification. In vivo evaluation is planned during the current grant year.

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Grant of the Month | April 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | April 1, 2006
PI Stephen Badylak, DVM, PhD, MD Co-PIs
  • Susan Braunhut, Ph.D., professor of biological sciences at the University of Massachusetts at Lowell
  • Lorraine Gudas, Ph.D., chairman of the pharmacology department and Revlon Pharmaceutical Professor of Pharmacology and Toxicology, Weill Medical College of Cornell University, New York City
  • Ellen Heber-Katz, Ph.D., professor, molecular and cellular oncogenesis program, The Wistar Institute in Philadelphia
    Shannon Odelberg, Ph.D., assistant professor, departments of internal medicine and neurobiology and anatomy, University of Utah, Salt Lake City
  • Hans-Georg Simon, Ph.D., a developmental biologist and assistant professor of pediatrics, Children’s Memorial Research Center and Northwestern University in Chicago

Title Mammalian Limb Restoration

Summary The regenerative ability of adult human tissues, organs, and appendages is typically very limited. The default mechanism of wound repair in humans and most other mammals is characterized by scar tissue formation. However, there is evidence for some site-specific regeneration-like processes during mammalian embryologic development and during the early postnatal period. In addition, there is lifelong self-renewal capability for selected cell populations such as hematopoietic cells, intestinal epithelium, and hepatocytes.

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Grant of the Month | March 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | March 1, 2006
PI J. Peter Rubin, MD; Kacey Marra, PhD; Albert Donnenberg, PhD; Vera Donnenberg, PhD; Stephen Badylak, DVM, PhD, MD Title Injectable Engineered Tissue for Cancer Reconstruction

Summary Breast cancer is endemic in the United States, with nearly 216,000 new cases expected this year (American Cancer Society statistics). For patients undergoing mastectomy, the loss of one or both breasts can cause significant discomfort and psychosocial distress.

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Grant of the Month | February 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | February 1, 2006
PI Jörg Gerlach, M.D., Ph.D Title 3D Culture of mES Cells in Four-Compartment Bioreactors

Summary Embryonic stem (ES) cell research and scale-up for development of possible clinical therapies is limited by the existing 2D dish culture methods. Our proposed studies present a new approach, in which ES cells are expanded under 3D medium perfusion conditions within four-compartment hollow fiber-based bioreactors. The design of the bioreactors allows integral oxygenation and efficient transfer of nutrients and waste products to and from the cells, cultured at high density involving minimal solute gradients within the cell compartment. Additionally, the interwoven fibers provide a scaffold allowing the cells to form 3D structures where the size of cellular aggregates is limited by the spacing between the hollow fibers. We propose that the well-controlled and versatile culture environment provided by our bioreactor is ideal for both large-scale expansion of undifferentiated ES cells and directed differentiation of ES cells using numerous strategies, including controlled exposure of the cells to molecular reagents and compartmentalized co-culture with mature cells.

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Grant of the Month | January 2006

By The McGowan Institute For Regenerative Medicine | Grant of the Month, Grant of the Month 2006 | January 1, 2006
PI John A. Kellum, MD

McGowan Institute Investigators: Gilles Clermont, MD; William Federspiel, PhD; Yoram Vodovotz, PhD; William Wagner, PhD
Title Systems Engineering of a Pheresis Intervention for Sepsis (SEPsIS)

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    • Admissions
    • Summer School
    • 2020 Scientific Retreat
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