Methods For The Treatment And Prevention Of Liver Disease

Inventors: Ira Jacob Fox: Aaron W. Bell: Taichiro Nishikawa: Alejandro Soto Gutierrez

Patent Number: 14/177,928

Abstract

The presently disclosed invention is directed to the discovery that hepatocyte nuclear factor 4 alpha (HNF4α; also known as NR2A1), a transcription factor, reverses hepatocyte dysfunction in an animal model of cirrhosis, resulting in improvement in hepatic function, treatment of cirrhosis, and prolonged survival.
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