Identification Of Mutations In Herpes Simplex Virus Envelope Glycoproteins That Enable Or Enhance Vector Retargeting To Novel Non-HSV Receptors (4)
Inventors: Hiroaki Uchida: Joseph C. Glorioso III: Justus Bernhard Cohen
Patent Number: 15/137,953
Abstract
The present invention provides an HSV vector comprising an envelope comprising one or more mutant gB and/or gH envelope glycoproteins, whereby the HSV vector exhibits at least 25% increased rate-of-entry after 20 minutes when assayed at 30° C. or 37° C. in Vero cells after first incubating at 4° C. relative to a control HSV comprising wild-type gB and gH glycoproteins. The invention also provides a viral stock comprising the inventive HSV vector.
