Use Of Targeted Nitroxide Agents In Preventing, Mitigating And Treating Radiation Injury

Inventors: Peter Wipf: Joel S. Greenberger M.D.: Michael W. Epperly Ph.D.: Jianfei Jiang: Natalia A. Belikova: Joshua G. Pierce: Valerian E. Kagan

Patent Number: 13/006,640

Abstract

Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.
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