TRPV1 modulatory gene product that affects TRPV1-specific pain behavioral responses identified in a functional screen of an HSV-based cDNA library
Inventors: William F. Goins, Joseph C. Glorioso, III, Justus Bernard Cohen, Bonnie L. Reinhart
Patent Number: US10851354B2
Abstract
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.
