Triggerably Dissolvable Hollow Fibers for Controlled Delivery

Inventors:  Jillian Tengood: Steven Little PhD: William R. Wagner PhD: Jorg C. Gerlach MD, PhD: Jianjun Guan: Alan J. Russell

Patent Number: 12/237,835

Abstract

Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded within a cell growth scaffold. The tubular structures are useful in growing 3-dimensional tissue structures because nutrients, cytokines or other cell growth and/or differentiation compounds, as well as drugs, such as antibiotics and steroids, can be administered over time, and the tubular structures can be dissolved non-invasively.
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