Self-Regulating Device for Modulating Inflammation

Inventors: Yoram Vodovotz: Gregory M. Constantine: Jorg Christian Gerlach MD, PhD: Qi Mi: Maxim Mikheev: David O. Okonkwo: Alexey Solovyev

Patent Number: 14/301,734

Abstract

A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.
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