Project Description

Selective Targeted Agents For Mitochondria (3)

Composition Comprising A TEMPO Derivative And A Membrane-Active Peptidyl Fragment Having A High Affinity With The Mitochondria

Inventors: Peter Wipf: Jingbo Xiao: Mitchell P. Fink: Valerian E. Kagan: Yulia Tyurina

Patent Number: 11/465,162


Compositions and methods are disclosed for treating an illness that is caused or associated with cellular damage or dysfunction which is caused by excessive mitochondrial production of reaction oxygen species (ROS). Compositions which act as mitochondria-selective targeting agents using specific structural signaling features recognizable by cells as mitochondrial targeting sequences are discussed. A method for delivering these agents effectively into cells and mitochondria where they act as electron scavengers by way of certain targeting sequences is also disclosed. Mitochondria dysfunction and cell death by way of apoptosis is inhibited as a result of the ROS-scavenging activity, thereby increasing the survival rate of the patient. In a preferred embodiment, the compositions and methods may be administered therapeutically in the field to patients with profound hemorrhagic shock so that survival could be prolonged until it is feasible to obtain surgical control of the bleeding vessels.
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