Nsp-interleukin-10 proteins and uses thereof
Inventors: Yangzi Jiang; Rocky Sung Chi Tuan
Patent Number: 11,084,857
Abstract
Disclosed herein are Nsp-IL10 polypeptides comprising an Nsp polypeptide and an IL10 polypeptide. In some embodiments, Nsp-IL10 polypeptide is capable of activating an NGF signaling pathway, an IL10 signaling pathway, or both. Also disclosed are methods for treating a disease comprising administering an Nsp-IL10 polypeptide. The methods include treating diseases associated with joint inflammation, such as osteoarthritis.
