Mitochondria-Targeted Inhibitors Of Cytochrome C Peroxidase For Protection From Apoptosis
Inventors: Valerian E. Kagan PhD, DSc: Detcho Anastassov Stoyanovsky: Michael W. Epperly Ph.D.: Joel S. Greenberger M.D.: Jeffrey Atkinson PhD: Jeffrey Stuart: Hulya Bayir
Patent Number: 13/675,208
The present application is directed to novel imidazole-substituted fatty acids that have been functionalized with an alkyl triphenylphosphonium group, compositions comprising these compounds and their use as inhibitors of cytochrome c peroxidase, in particular for the treatment and prevention of apoptosis.