Methods For Preparation Of A Terminally Sterilized Hydrogel Derived From Extracellular Matrix

Inventors:  Timothy Joseph Keane Jr: Stephen Francis Badylak DVM, PhD, MD: Christopher Lee Dearth: Neill Jordon Turner

Patent Number: 15/127,707

Abstract

Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
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