Identication Of Peptides That Facilitate Uptake And Cytoplasmic And/Or Nuclear Transport Of Proteins, DNA And Virues
Inventors: Raymond Frizzell Ph.D.: Paul D. Robbins: Zhibao Mi: Joseph C. Glorioso III: Andrea Gambotto M.D.
Patent Number: 09/653,182
The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of the peptides, and methods of use for the peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro.