Project Description

HMGB1 Expression And Protective Role Of Semapimod In NEC

Inventors: Vidal F de la Cruz Jr: Thais Sielecki-Dzurdz: Henri R. Ford: Ruben Zamora

Patent Number: 12/879,144

Abstract

Methods are described, which include the administration of semapimod or guanylhydrazone containing compounds, salt thereof, or a combination of the compound and a salt thereof for the inhibition, treatment, and/or prevention of any of NEC,
a condition associated with the release of HMGB1, a
condition associated with the release of iNOS protein, a
condition associated with the release of Bax protein, a
condition associated with the release of Bad protein, a
condition associated with the release of COX-2 protein, or a
condition associated with the release of RAGE, or a
combination thereof to a subject in need thereof.
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