Fractionating Extracellular Matrix to Modulate Bioactivity and the Host Response

Inventors: Stephen Francis Badylak DVM, PhD, Md: Peter F. Slivka

Patent Number: 15/306,262

Abstract

Provided herein are methods of fractionating extracellular matrix (ECM) materials, producing soluble and structural fractions having different immunological activities. Also provided are compositions and devices comprising the fractions. A method of immune modulation also is provided in which an amount of a soluble or structural ECM fraction prepared according to the methods provided herein is administered to a patient in an amount effective to modulate immune function, for example macrophage function.
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