A method for making a modified release composition, comprising:
selecting a desired active agent and polymer matrix for formulating into a modified release composition;
assessing degradation effect on release of the active agent from the composition including plotting polymer molecular weight (Mwr) at onset of active agent release vs. active agent molecular weight (MwA);
predicting performance of multiple potential formulations for the composition based on the degradation assessment and average polymer matrix initial molecular weight (Mwo) to define a library of building blocks;
determining the optimal ratio of the building blocks to satisfy a specified release profile; and
making a modified release composition based on the optimal ratio determination.