Compositions For Modulating An XBP1 Pathway In A Keratinocyte And Methods Of Use

Inventors: Louis D. Falo Jr: Zhaoyang You

Patent Number: PCT/US2016/039265

Abstract

Provided herein are compositions and methods for increasing an immune response in a subject, immunizing a subject and/or treating a disease in a subject that relate to keratinocytes. It is a surprising finding of the present invention that modulation of an XBP1 pathway creates a keratinocyte that is itself an immune modulator, or adjuvant. In some embodiments, the concentration of antigen is increased in the vicinity of the keratinocyte, further increasing the immune response by effector cells within that vicinity.
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