Activators Of CXCR3 For The Treatment Of Angiopathies Of The Eye

CXCR3 Receptor Activator: Biologically Active Platelet Factor 4 (PF4) Peptide Fragment

Inventors: Alan H. Wells: Cecelia C. Yates: Joel Steven Schuman

Patent Number: US 15/245,502

Abstract

The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by administering an activator of C-X-C chemokine receptor 3 (CXCR3). In some embodiments, the activator of CXCR3 is interferon-γ-inducible 10 kDa protein (IP-10) or a fragment or variant thereof, such as a fragment comprising or consisting of the C-terminal α-helix of IP-10. In other embodiments, the activator of CXCR3 is platelet factor 4 (PF4) or a fragment or variant thereof.
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