TRPV1 Modulatory Gene Product That Affects TRPV1-Specific Pain Behavioral Responses Identified In A Functional Screen Of An HSV-Based cDNA Library
Expression Cassette Comprises A Nucleic Acid Sequence Encoding PP1α, The Nucleic Acid Sequence Encoding PP1α Is Operably Linked To The Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Promoter
Inventors: William F. Goins Ph.D.: Joseph C. Glorioso III: Justus Bernhard Cohen: Bonnie L. Reinhart
Patent Number: 14/690,038
Abstract
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.
