Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria
Inventors: Rama K. Mallampalli: Beibei Chen: Charleen T. Chu: Yuan Liu
Patent Number: 11,242,339
Abstract
A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R3-R7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy;R8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3.
