Identification Of Mutations In Herpes Simplex Virus Envelope Glycoproteins That Enable Or Enhance Vector Retargeting To Novel Non-H Receptors
HSV Vector Comprising A Mutant Gb And/Or A Mutant Gh Glycoprotein, Where The Viral Envelope Further Comprises A Non-Native Ligand Specific For Protein
Inventors: Justus Bernhard Cohen: Hiroaki Uchida: Joseph C. Glorioso III: Paola Grandi
Patent Number: 15/409,245
Abstract
In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.
