{"id":433,"date":"2019-10-03T21:15:57","date_gmt":"2019-10-03T21:15:57","guid":{"rendered":"https:\/\/mirm-pitt.net\/technologies\/?p=433"},"modified":"2019-10-03T21:15:57","modified_gmt":"2019-10-03T21:15:57","slug":"designing-3d-printed-materials-to-help-the-body-heal-itself","status":"publish","type":"post","link":"https:\/\/mirm-pitt.net\/technologies\/2019\/10\/03\/designing-3d-printed-materials-to-help-the-body-heal-itself\/","title":{"rendered":"Designing 3D-Printed Materials to Help the Body Heal Itself"},"content":{"rendered":"<p>In the laboratory of McGowan Institute for Regenerative Medicine affiliated faculty member <a href=\"https:\/\/mirm-pitt.net\/our-people\/faculty-staff-bios\/prashant-n-kumta-phd\/\">Prashant Kumta, PhD<\/a>, the Edward R. Weidlein Chair Professor at the University of Pittsburgh Swanson School of Engineering and School of Dental Medicine and professor in the Departments of BioEngineering, Chemical and Petroleum Engineering, Mechanical Engineering and Materials Science, and Oral Biology, one of the visions is to revolutionize metallic biomaterials and technologies to create life changing devices. This will lead to engineered systems that will interface with the human body to prolong and improve quality of life, specifically with craniofacial and orthopedic applications. Dr. Kumta and his team\u2019s goal is to engineer logical and clinically relevant options that could regenerate mineralized tissue (bone\/tooth) formation utilizing a unique combination of evolutionary load-bearing biodegradable materials (metals), growth factors, and cell therapy.<\/p>\n<p><img decoding=\"async\" class=\"alignright size-medium wp-image-729\" src=\"https:\/\/mirm-pitt.net\/wp-content\/uploads\/2015\/07\/3-D-Printing-300x182.jpg\" alt=\"3-D Printing\" width=\"279\" height=\"169\" \/>Recently, Rosanne Skirble of Voice of America News reported (<a href=\"http:\/\/www.voanews.com\/content\/scientists-develop-biodegradable-parts-fix-\/2804911.html\" target=\"_blank\" rel=\"noopener noreferrer\">video here<\/a>) that Dr. Kumta and his team of graduate students are designing 3D-printed materials that are a match for the patient\u2019s body, and are absorbed or excreted as new tissue grows and the wound heals. In the laboratory, Dr. Kumta\u2019s team has developed both magnesium and iron alloys to use as the materials\u2019 base. He calls magnesium \u2014 a mineral needed for more than 300 biochemical reactions in the body \u2014 \u201ca perfect fit\u201d for the technique.<\/p>\n<p>\u201cIt has the mechanical characteristics that meet natural bone, both from the strength [and] the toughness as well as the density. It has the perfect density that will match with natural bone,\u201d he said.<br \/>\nDr. Kumta\u2019s team is also working with a novel formulation of calcium phosphate putty that can be injected to fill spaces between fractured bones. A 3D-printed biodegradable plate or screw would hold that filler in place.<\/p>\n<p>\u201cThe fixation plate will provide the mechanical strength needed to carry the load, and the bone-wide filler would help provide the healing and the bone formation,\u201d he said.<\/p>\n<p>Pre-clinical trials are now underway in animals. Dr. Kumta said the work is revolutionary, offering the prospect of a better outcome for the patient.<br \/>\n\u201cRather than implanting a screw or plate or joint,\u201d he said, \u201cdoctors could give the body\u2019s own regenerative ability a more effective method to heal itself.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the laboratory of McGowan Institute for Regenerative Medicine affiliated [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":434,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[40],"tags":[],"_links":{"self":[{"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/posts\/433"}],"collection":[{"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/comments?post=433"}],"version-history":[{"count":1,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/posts\/433\/revisions"}],"predecessor-version":[{"id":435,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/posts\/433\/revisions\/435"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/media\/434"}],"wp:attachment":[{"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/media?parent=433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/categories?post=433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/tags?post=433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}