{"id":4040,"date":"2023-02-20T16:17:37","date_gmt":"2023-02-20T16:17:37","guid":{"rendered":"https:\/\/mirm-pitt.net\/technologies\/?post_type=avada_portfolio&p=4040"},"modified":"2023-02-20T16:17:37","modified_gmt":"2023-02-20T16:17:37","slug":"chemical-inhibition-of-the-e3-ligase-subunit-fbxo7-confers-neuroprotection-and-anti-inflammatory-activity-by-stabilizing-mitochondria","status":"publish","type":"avada_portfolio","link":"https:\/\/mirm-pitt.net\/technologies\/patents\/chemical-inhibition-of-the-e3-ligase-subunit-fbxo7-confers-neuroprotection-and-anti-inflammatory-activity-by-stabilizing-mitochondria\/","title":{"rendered":"Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria"},"content":{"rendered":"

Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria<\/h1>\n
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Inventors:<\/strong> Rama K. <\/span>Mallampalli<\/span>: Beibei Chen: <\/span>Charleen<\/span> T. <\/span>Chu: Yuan<\/span> Liu<\/span>\u00a0<\/span>
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Patent Number:<\/strong> 11,242,339<\/p>\n

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Abstract<\/h3>\n
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A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R3-R7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy;R8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3.<\/div>\n<\/section>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>
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