{"id":3987,"date":"2023-02-16T17:06:41","date_gmt":"2023-02-16T17:06:41","guid":{"rendered":"https:\/\/mirm-pitt.net\/technologies\/?post_type=avada_portfolio&p=3987"},"modified":"2023-02-16T17:06:41","modified_gmt":"2023-02-16T17:06:41","slug":"compounds-and-methods-of-treating-retinal-degeneration","status":"publish","type":"avada_portfolio","link":"https:\/\/mirm-pitt.net\/technologies\/patents\/compounds-and-methods-of-treating-retinal-degeneration\/","title":{"rendered":"Compounds and methods of treating retinal degeneration"},"content":{"rendered":"

Compounds and methods of treating retinal degeneration<\/h1>\n
\n
\n
\n

<\/h2>\n<\/section>\n<\/div>\n<\/div>\n
\n
\n
\n

<\/h2>\n<\/section>\n<\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/div>

Inventors: <\/strong>Krzysztof Palczewski: Yuanyuan Chen
\n<\/strong><\/p>\n

Patent Number:<\/strong> 11,191,752<\/p>\n

\n
\n
\n

Abstract<\/h3>\n
\n
\n
This application relates to compounds and methods of treating retinal degeneration associated with inherited rhodopsin mutations in the ocular tissue of a subject. The retinal degeneration, can include, for example, macular degeneration, a including age-related macular degeneration, Stargardt disease, and retinitis pigmentosa. The retinitis pigmentosa can include autosomal dominate retinitis pigmentosa associated with a P23H RHO mutation. A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I), wherein the compound of formula (I) acts as a chaperone of rhodopsin.<\/div>\n<\/section>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>
<\/div>
<\/div>
<\/div>