{"id":3505,"date":"2021-10-13T15:15:01","date_gmt":"2021-10-13T15:15:01","guid":{"rendered":"https:\/\/mirm-pitt.net\/technologies\/?post_type=avada_portfolio&#038;p=3505"},"modified":"2021-10-13T15:15:01","modified_gmt":"2021-10-13T15:15:01","slug":"oncolytic-hsv-vector-5","status":"publish","type":"avada_portfolio","link":"https:\/\/mirm-pitt.net\/technologies\/patents\/oncolytic-hsv-vector-5\/","title":{"rendered":"Oncolytic HSV vector"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0.9);background-position: center center;background-repeat: no-repeat;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px;margin-bottom: 0px;margin-top: 0px;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><h2 id=\"title\" class=\"scroll-target style-scope patent-result\">Oncolytic HSV vector<\/h2>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_2_3 2_3 fusion-two-third fusion-column-first\" style=\"width:66.666666666667%;width:calc(66.666666666667% - ( ( 4% ) * 0.66666666666667 ) );margin-right: 4%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p><strong>Inventors: <\/strong>Hiroaki Uchida, Justus B. Cohen, Joseph C. Glorioso, III, Paola Grandi<\/p>\n<p><strong>Patent Number: <\/strong>US10576115B2<\/p>\n<div class=\"horizontal layout style-scope patent-result\">\n<div class=\"flex-3 style-scope patent-result\">\n<section id=\"abstract\" class=\"style-scope patent-result\">\n<h3 class=\"flex style-scope patent-result\">Abstract<\/h3>\n<div class=\"layout horizontal style-scope patent-text\">\n<section id=\"text\" class=\"flex style-scope patent-text\">\n<div id=\"p-0001\" class=\"abstract style-scope patent-text\">The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.<\/div>\n<\/section>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:50%;width:calc(50% - ( ( 4% ) * 0.5 ) );margin-right: 4%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-align-block\"><style>.fusion-body .fusion-button.button-1{border-radius:0px 0px 0px 0px;}<\/style><a class=\"fusion-button button-flat fusion-button-default-size button-default button-1 fusion-button-default-span fusion-button-default-type\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/patents.google.com\/patent\/US10576115B2\/en?oq=10%2c576%2c115\" style=\"width:calc(100%);\"><span class=\"fusion-button-text\">View Google Patent Page<\/span><\/a><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-1 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:50%;width:calc(50% - ( ( 4% ) * 0.5 ) );margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-align-block\"><style>.fusion-body .fusion-button.button-2{border-radius:0px 0px 0px 0px;}<\/style><a class=\"fusion-button button-flat fusion-button-default-size button-default button-2 fusion-button-default-span fusion-button-default-type\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/mirm-pitt.net\/technologies\/wp-content\/uploads\/2021\/08\/US10576115.pdf\" style=\"width:calc(100%);\"><span class=\"fusion-button-text\">Download PDF<\/span><\/a><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_3 1_3 fusion-one-third fusion-column-last\" style=\"width:33.333333333333%;width:calc(33.333333333333% - ( ( 4% ) * 0.33333333333333 ) );margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><h3 id=\"title\" class=\"scroll-target style-scope patent-result\"><\/h3>\n<\/div><style type=\"text\/css\">.fusion-gallery-1 .fusion-gallery-image {border:0px solid #f6f6f6;}<\/style><div class=\"awb-gallery-wrapper awb-gallery-wrapper-1 button-span-no\"><div class=\"fusion-gallery fusion-gallery-container fusion-grid-2 fusion-columns-total-2 fusion-gallery-layout-grid fusion-gallery-1\" style=\"margin:-2px;\"><div style=\"padding:2.5px;\" class=\"fusion-grid-column fusion-gallery-column fusion-gallery-column-2 hover-type-zoomin\"><div class=\"fusion-gallery-image\"><a href=\"https:\/\/mirm-pitt.net\/technologies\/wp-content\/uploads\/2021\/08\/US10576115-20200303-D00009.png\" rel=\"noreferrer\" data-rel=\"iLightbox[gallery_image_1]\" class=\"fusion-lightbox\" target=\"_self\"><img decoding=\"async\" src=\"https:\/\/mirm-pitt.net\/technologies\/wp-content\/uploads\/2021\/08\/US10576115-20200303-D00009.png\" width=\"2055\" height=\"2277\" alt=\"\" title=\"US10576115-20200303-D00009\" aria-label=\"US10576115-20200303-D00009\" class=\"img-responsive wp-image-3504\"  \/><\/a><\/div><\/div><div style=\"padding:2.5px;\" class=\"fusion-grid-column fusion-gallery-column fusion-gallery-column-2 hover-type-zoomin\"><div class=\"fusion-gallery-image\"><a href=\"https:\/\/mirm-pitt.net\/technologies\/wp-content\/uploads\/2021\/08\/US10576115-20200303-D00005.png\" rel=\"noreferrer\" data-rel=\"iLightbox[gallery_image_1]\" class=\"fusion-lightbox\" target=\"_self\"><img decoding=\"async\" src=\"https:\/\/mirm-pitt.net\/technologies\/wp-content\/uploads\/2021\/08\/US10576115-20200303-D00005.png\" width=\"1589\" height=\"2580\" alt=\"\" title=\"US10576115-20200303-D00005\" aria-label=\"US10576115-20200303-D00005\" class=\"img-responsive wp-image-3503\"  \/><\/a><\/div><\/div><div class=\"clearfix\"><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","format":"standard","meta":[],"portfolio_category":[25,80],"portfolio_skills":[],"portfolio_tags":[],"_links":{"self":[{"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/avada_portfolio\/3505"}],"collection":[{"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/comments?post=3505"}],"version-history":[{"count":1,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/avada_portfolio\/3505\/revisions"}],"predecessor-version":[{"id":3506,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/avada_portfolio\/3505\/revisions\/3506"}],"wp:attachment":[{"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/media?parent=3505"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/portfolio_category?post=3505"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/portfolio_skills?post=3505"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/mirm-pitt.net\/technologies\/wp-json\/wp\/v2\/portfolio_tags?post=3505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}