{"id":2616,"date":"2020-05-28T18:28:57","date_gmt":"2020-05-28T18:28:57","guid":{"rendered":"https:\/\/mirm-pitt.net\/technologies\/?post_type=avada_portfolio&#038;p=2616"},"modified":"2020-07-09T15:54:39","modified_gmt":"2020-07-09T15:54:39","slug":"1-trpv1-modulatory-gene-product-that-affects-trpv1-specific-pain-behavioral-responses-identified-in-a-functional-screen-of-an-hsv-based-cdna-library","status":"publish","type":"avada_portfolio","link":"https:\/\/mirm-pitt.net\/technologies\/patents\/1-trpv1-modulatory-gene-product-that-affects-trpv1-specific-pain-behavioral-responses-identified-in-a-functional-screen-of-an-hsv-based-cdna-library\/","title":{"rendered":"TRPV1 Modulatory Gene Product That Affects TRPV1-Specific Pain Behavioral Responses Identified In A Functional Screen Of An HSV-Based cDNA Library"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0.9);background-position: center center;background-repeat: no-repeat;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px;margin-bottom: 0px;margin-top: 0px;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><h2 id=\"title\" class=\"scroll-target style-scope patent-result\">TRPV1 Modulatory Gene Product That Affects TRPV1-Specific Pain Behavioral Responses Identified In A Functional Screen Of An HSV-Based cDNA Library<\/h2>\n<p>Expression Cassette Comprises A Nucleic Acid Sequence Encoding PP1\u03b1, The Nucleic Acid Sequence Encoding PP1\u03b1 Is Operably Linked To The Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Promoter<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_2_3 2_3 fusion-two-third fusion-column-first\" style=\"width:66.666666666667%;width:calc(66.666666666667% - ( ( 4% ) * 0.66666666666667 ) );margin-right: 4%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p><strong>Inventors:<\/strong> William F. Goins Ph.D.: Joseph C. Glorioso III: Justus Bernhard Cohen: Bonnie L. Reinhart<\/p>\n<p><strong>Patent Number:<\/strong> 14\/690,038<\/p>\n<div class=\"horizontal layout style-scope patent-result\">\n<div class=\"flex-3 style-scope patent-result\">\n<section id=\"abstract\" class=\"style-scope patent-result\">\n<h3 class=\"flex style-scope patent-result\">Abstract<\/h3>\n<div class=\"layout horizontal style-scope patent-text\">\n<section id=\"text\" class=\"flex style-scope patent-text\">\n<div id=\"p-0001\" class=\"abstract style-scope patent-text\">The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1\u03b1 in neurons. The invention also provides HSV vectors for expressing PP1\u03b1 within neurons and compositions comprising such vectors.<\/div>\n<\/section>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:50%;width:calc(50% - ( ( 4% ) * 0.5 ) );margin-right: 4%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 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