{"id":1926,"date":"2020-05-20T18:32:41","date_gmt":"2020-05-20T18:32:41","guid":{"rendered":"https:\/\/mirm-pitt.net\/technologies\/?post_type=avada_portfolio&p=1926"},"modified":"2020-07-08T05:49:29","modified_gmt":"2020-07-08T05:49:29","slug":"identification-of-mutations-in-herpes-simplex-virus-envelope-glycoproteins-that-enable-or-enhance-vector-retargeting-to-novel-non-h-receptors","status":"publish","type":"avada_portfolio","link":"https:\/\/mirm-pitt.net\/technologies\/patents\/identification-of-mutations-in-herpes-simplex-virus-envelope-glycoproteins-that-enable-or-enhance-vector-retargeting-to-novel-non-h-receptors\/","title":{"rendered":"Identification Of Mutations In Herpes Simplex Virus Envelope Glycoproteins That Enable Or Enhance Vector Retargeting To Novel Non-H Receptors"},"content":{"rendered":"

Identification Of Mutations In Herpes Simplex Virus Envelope Glycoproteins That Enable Or Enhance Vector Retargeting To Novel Non-H Receptors<\/h2>\n

HSV Vector Comprising A Mutant Gb And\/Or A Mutant Gh Glycoprotein, Where The Viral Envelope Further Comprises A Non-Native Ligand Specific For Protein<\/p>\n<\/div>

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Inventors:<\/strong> Justus Bernhard Cohen: Hiroaki Uchida: Joseph C. Glorioso III: Paola Grandi<\/p>\n

Patent Number:<\/strong> 15\/409,245<\/p>\n

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Abstract<\/h3>\n
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In one embodiment, the invention provides an HSV vector comprising a mutant gB and\/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and\/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.<\/div>\n<\/section>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>
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