Dr. Duncan is an Assistant Professor in the Department of Pathology at the University of Pittsburgh. He holds a secondary appointment in the Department of Bioengineering of the Swanson School of Engineering at Pitt. He is a member of the University of Pittsburgh Graduate Faculty, Program in Cellular and Molecular Pathology, the Pittsburgh Liver Research Center, and the UPMC Hillman Cancer Center Genome Stability Program.
Dr. Duncan graduated from the University of North Carolina at Chapel Hill with a BS in Biology in 1996. He attended graduate school at Duke University where he earned a PhD in 2005. Dr. Duncan's graduate work focused on hematopoietic stem cell biology in Dr. Tannishtha Reya's Laboratory in the Department of Pharmacology and Cancer Biology. From 2005 to 2011, Dr. Duncan was a postdoctoral fellow in Dr. Markus Grompe's Lab in the Oregon Stem Cell Center, Oregon Health and Science University. As an NIH National Research Service Award Fellow, he investigated liver regeneration. Dr. Duncan was recruited to the University of Pittsburgh in 2012 by the Department of Pathology and McGowan Institute for Regenerative Medicine.
Dr. Duncan’s comprehensive, NIH-funded program seeks to understand how hepatocyte chromosome variations influence liver function and disease, particularly the role of diploid and polyploid cells. The lab has developed unique approaches to investigate liver regeneration and injury. In the most basic sense, liver diseases begin with some form of liver damage, which, in turn, impairs the liver’s ability to regenerate new, healthy tissue. Thus, liver failure results from direct damage combined with a failure to self-repair. Current studies investigate liver repair from the context of regeneration, focusing on the liver’s natural ability to regenerate in response to acute and chronic injury.
Dr. Duncan is on the Editorial Board of the American Journal of Pathology and Organogenesis and is an ad hoc reviewer for multiple journals including, Nature, Developmental Cell and Hepatology.
View a list of Dr. Duncan’s publications here.